β-七叶皂苷钠联合奥拉西坦对急性脑梗死患者血浆同型半胱氨酸和单核细胞趋化因子-1的影响
Effects of β-aescine sodium plus oxiracetam on plasma homocysteine and MCP-1 protein in patients with acute cerebral infarction
目的 探讨β-七叶皂苷钠联合奥拉西坦对急性脑梗死患者血浆同型半胱氨酸(Hcy)和单核细胞趋化因子-1(MCP-1)的影响.方法 117例急性脑梗死患者按数字表随机分为两组,观察组60例,对照组57例,对照组采用常规治疗,观察组在常规治疗的基础上加用β-七叶皂苷钠联合奥拉西坦.两组共治疗14 d.测定患者治疗前后血浆Hcy和MCP-1.结果 观察组总有效率为95.0%,对照组总有效率为84.5%,两组总有效率差异有统计学意义(x2 =5.801,P<0.05).两组治疗后患者血浆Hcy和MCP-1均有明显降低(t =9.551、4.296、2.001、21.070,P<0.05,P<0.01),且与对照组比较,观察组治疗后降低更明显(t=4.997、25.276,均P<0.05).结论 β-七叶皂苷钠联合奥拉西坦可以明显减少急性脑梗死患者血浆Hcy和MCP-1的表达.
更多Objective To study the effects of β-aescine sodium plus oxiracetam on plasma homocysteine (Hcy) and monocyte chemotactic factor(MCP-1) protein in patients with acute cerebral infarction.Methods 117 patients with acute cerebral infarction were randomly divided into the two groups,the observation group (n =60 cases) and the control group (n =57 cases).The patients in the control group were treated with the conventional treatment,while the patients in the observation group were treated with joint treatment ofβ-aescine sodium plus oxiracetam.They were treated for 14 days.Plasma Hcy and MCP-1 were detected.Results The total efficicies were 95.0% in the observation group and 84.5% in the control group.There was a significant difference between two groups (x2 =5.801,P <0.05).Plasma Hcy and MCP-1 were decreased after treatment (t =9.551,4.296,2.001,21.070,P < 0.05,P <0.01).Plasma Hcy and MCP-1 in the observation group were lower than these in the control group (t =4.997,25.276,all P < 0.05).Conclusion β-aescine sodium plus oxiracetam can decrease plasma Hcy and MCP-1 in patients with acute cerebral infarction.
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