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首发抑郁症患者血清同型半胱氨酸水平及其与 P300的关系

The serum homocysteine levels in patients with first-episode depression and its relationship with P300

摘要:

目的:研究首发抑郁症患者的血清同型半胱氨酸( Hcy)水平与事件相关电位( ERP) P300之间的关系。方法选取117例首发抑郁症患者(病例组)及110例健康志愿者(健康对照组),采用酶联免疫法测定两组的血清Hcy水平,采用深圳Brain Master脑诱发电位系统完成视觉P300的测定。结果病例组血清Hcy水平为(14.0±9.8)μmol/L,高于健康对照组的(10.5±7.5)μmol/L(t=-3.087,P<0.05)。病例组N1、N2潜伏期为(91.4±18.6)ms、(235.4±30.5)ms,较健康对照组的(88.6±13.0)ms、(204.3±20.3)ms延长(t=1.305,8.990,均P<0.01),病例组P3潜伏期为(359.5±30.0)ms,较健康对照组(327.2±41.8)ms延长(t=6.685,P<0.05)。病例组靶P3、非靶P2波幅为(4.1±2.0)μV、(4.2±1.9)μV,显著低于健康对照组的(6.8±3.8)μV、(6.6±3.6)μV( t=-6.694,-6.485,均P<0.01)。 HHcy病例组P2潜伏期为(194.4±13.6)ms,较非HHcy病例组的(163.1±21.8)ms延长(t=8.486,P<0.01),HHcy病例组P3潜伏期为(357.0±24.5)ms,较非HHcy病例组的(337.1±45.5)ms延长(t=2.645,P<0.05)。 HHcy病例组靶P3、非靶P2波幅为(5.4±1.5)μV、(5.2±1.2)μV,显著低于非HHcy病例组的(5.8±3.8)μV、(5.4±3.2)μV(t=-0.745,-0.208,均P<0.01)。结论首发抑郁症患者血清Hcy水平升高,且P300潜伏期延长、波幅降低,Hcy代谢失衡与抑郁症患者的认知功能损害相关。

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abstracts:

Objective To study the relationship between the serum homocysteine ( Hcy ) levels in patients with first-episode depression and event related potentials ( ERP ) P300.Methods 117 first-episode depressive patients were selected as the case group,and 110 healthy volunteers were selected as the health control group,the de-termination of serum Hcy levels in the two groups were detected by enzyme linked immunosorbent assay,measured by the Shenzhen Brain Master brain evoked potential system to complete the visual P300.Results The serum Hcy levels of the case group was (14.0 ±9.8)μmol/L,which was higher than (10.5 ±7.5)μmol/L of the health control group (t=-3.087,P <0.05).The N1,N2 incubation period of the case group were (91.4 ±18.6) ms,(235.4 ± 30.5)ms,respectively,which were longer than (88.6 ±13.0)ms,(204.3 ±20.3)ms of the health control group(t=1.305,8.990,all P<0.01);The P3 incubation period of the case group were (359.5 ±30.0)ms,which was longer than (327.2 ±41.8)ms of the health control group(t=6.685,P<0.05).The target P3,non-target P2 amplitude of the case group were (4.1 ±2.0)μV,(4.2 ±1.9)μV,respectively,which were singnificantly lower than (6.8 ± 3.8)μV,(6.6 ±3.6) μV of the health control group( t=-6.694,-6.485,all P<0.01).The P2 incubation period of Hcy case group was (194.4 ±13.6) ms,which was longer than (163.1 ±21.8) ms of the non Hcy case group(t=8.486,P<0.01).The P3 incubation period of Hcy case group was (357.0 ±24.5)ms,which was longer than (337.1 ±45.5)ms of the non Hcy case group(t=2.645,P<0.05).The target P3,non-target P2 amplitude of the Hcy case group were (5.4 ±1.5)μV,(5.2 ±1.2) μV,which were significantly lower than (5.8 ±3.8)μV, (5.4 ±3.2)μV of the Hcy case group(t=-0.745,-0.208,all P<0.01).Conclusion The serum Hcy levels in patients with first-episode depression increased, and P300 latency, amplitude decreased, the cognitive function is related to Hcy metabolism disorder and depression damage.

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