曲美他嗪联合阿托伐他汀对冠心病心力衰竭患者心功能及血浆脑钠肽的影响
Influence of trimetazidine combined with atorvastatin on heart function and the BNP level in patients with coronary heart failure
目的:探讨曲美他嗪联合阿托伐他汀对冠心病心力衰竭患者心功能及血浆脑钠肽的影响。方法采用回顾性分析法,选择冠心病心力衰竭患者400例,其中对照组194例通过常规抗心衰方案治疗,观察组206例在常规治疗基础上加用曲美他嗪联合阿托伐他汀,比较两组治疗效果及心功能指标、血浆脑钠肽水平的变化。结果观察组治疗有效率为91.26%,明显高于对照组的76.29%,差异有统计学意义(χ2=16.667,P <0.05)。经过治疗,两组研究对象心脏指数(CI)、每搏量(SV)、心搏出量(CO)、左室射血分数(LEVF)较治疗前均显著提高,研究组 CI、SV、CO、LEVF 高于对照组(t =2.505、2.851、3.308、3.452,均 P <0.05)。结论曲美他嗪联合阿托伐他汀治疗冠心病心力衰竭的治疗效果良好,可以显著降低血浆脑钠肽水平,并改善心功能,具有较好的临床应用价值。
更多Objective To investigate the influence of trimetazidine combined with atorvastatin on heart func-tion and the BNP level in patients with cornary heart failure.Methods The clinical data of 400 patients with cornary heart disease were retrospectively analyzed.194 patients in the control group were treated with conventional treatment, 206 patients in the observation group were treated with trimetazidine combined with atorvastatin on the basis of the control group.The treatment effect,cardiac function and BNP level were observed and compared.Results The effec-tive rate of the observation group was 91.26%,which was significantly higer than 76.29% of the control group (χ2 =16.667,P <0.05).After treatment,the cardiac index,stroke volume,cardiac output,left ventricular ejection fraction and BNP level of the two groups were significantly higher than before treatment,and those in the observation group were significantly higher than the control group(t =2.505,2.851,3.308,3.452,all P <0.05).Conclusion Trime-tazidine combined with atorvastatin in treatment of cornary heart failure has good curative effect,it can reduce the serum level of BNP,improve cardiac function significantly,which is of great value for clinical use.
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