奥硝唑与甲硝唑治疗滴虫性阴道炎的疗效比较
Comparison of the clinical effect of ornidazole and metronidazole in the treatment of trichomonal vaginitis
目的:比较奥硝唑与甲硝唑治疗滴虫性阴道炎中的临床疗效。方法选择滴虫性阴道炎患者64例,完全随机对照法分为两组,观察组和对照组,每组32例,观察组采用奥硝唑治疗,对照组采用甲硝唑治疗,治疗1个疗程后对比两组患者的临床疗效,黄色白带、尿频、外阴瘙痒、尿痛等临床症状的改善情况以及不良反应发生情况。结果奥硝唑组31例有效,临床总有效率为96.87%;甲硝唑组26例有效,临床总有效率为81.75%。奥硝唑组的临床有效率显著优于甲硝唑组(χ2=6.869,P <0.05)。治疗前,奥硝唑组与甲硝唑组患者的临床症状差异无统计学意义(P >0.05);治疗后,奥硝唑组黄色白带、尿频、外阴瘙痒、尿痛等症状的发生率显著低于甲硝唑组(χ2=6.594、8.256、6.783、6.469,均 P <0.05)。奥硝唑组的不良反应显著低于甲硝唑组(χ2=8.325,P <0.05)。结论治疗滴虫性阴道炎时,奥硝唑的临床有效率显著优于甲硝唑组,临床症状改善更显著,安全性更高,值得临床推广应用。
更多Objective To observe and compare the clinical efficacy of ornidazole and metronidazole in the treatment of trichomonal vaginitis.Methods We selected 64 patients with trichomonal vaginitis who were treated in our hospiatl from January 201 3 to December 201 4,and they were divided into the observation group and the control group,each group had 32 cases.The observation group was treated with ornidazole,while the control group was treated with metronidazole.The clinical efficacy,yellow leucorrhea,frequent urination,and other clinical symptoms and adverse reactions of the two groups were compared.Results The total effective rate of the ornidazole group was 96.875%,which of the metronidazole group was 81 .75%.The ornidazole group was significantly better than the met-ronidazole group,and there was significant difference (χ2 =6.869,P <0.05).There were no significant differences of the clinical symptoms between the two groups(P >0.05).After treatment,the clinical symptoms incindence:yellow leucorrhea,frequent urination,etc of the ornidazole group was significantly lower than those of the metronidazole group,and there were significant differences (χ2 =6.594,8.256,6.783,6.469,all P <0.05 ).The incidence of adverse reaction of the ornidazole group was significantly lower than that of the metronidazole group,and there was significant difference (χ2 =8.325,P <0.05).Conclusion The clinical efficacy of ornidazole for the treament of trichomonas vaginitis was significantly better than metronidazole,and the clinical symptoms improved more significantly, it has higher safety and worthy of clinical application.
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