红花黄色素联合胰激肽原酶治疗早期糖尿病肾病的临床观察
Clinical observation of the effect of safflower yellow combined with kallidinogenase on early diabetic nephropathy
目的:探讨红花黄色素联合胰激肽原酶治疗早期糖尿病肾病的临床疗效。方法将80例早期糖尿病肾病患者采用数字表法随机分为红花黄色素组(治疗组)和对照组各40例,两组均给予合理饮食与运动,积极控制血糖、血脂、血压等,对照组给予胰激肽原酶40 U加入0.9%氯化钠注射液2 mL中肌内注射,1次/d;治疗组在对照组基础上,加用红花黄色素注射液100 mg加入5%葡萄糖注射液250 mL、普通胰岛素3 u静脉滴注,1次/d。两组均以3周为1个疗程。观察两组治疗前后24 h尿微量白蛋白浓度(24 h U-ALB)及尿白蛋白排泄率(UAER)的变化。结果治疗前,对照组24 h U-ALB、UAER分别为(100.44±65.72)mg/L、(117.31±68.32)μg/min,治疗组分别为(123.57±63.28)mg/L、(138.57±50.82)μg/min,两组差异均无统计学意义(t=1.098、1.056,均P>0.05)。治疗后,对照组24 h U-ALB、UAER分别为(79.39±65.33)mg/L、(92.68±67.95)μg/min,治疗组分别为(71.87±60.03) mg/L、(62.52±38.64)μg/min,两组治疗前后比较,差异均有统计学意义(对照组:t=5.903、6.069;治疗组:t=6.779、12.612,均P<0.05);两组治疗后24 h U-ALB差异无统计学意义(t=-0.386,P>0.05),UAER差异有统计学意义(t=-2.029,P<0.05)。结论红花黄色素联合胰激肽原酶可减少糖尿病肾病早期患者的尿白蛋白排泄率,延缓糖尿病肾病的进展。
更多Objective To assess the clinical effect of safflower yellow combined with kallidinogenase on ear-ly diabetic nephropathy.Methods 80 early diabetic nephropathy patients were all given diet control, appropriate exerciseand positive controlled blood sugar,blood fat,blood pressure.They were randomly divided into two groups,the control group was intramuscularly given kallidinogenase 40U dissolved in sodium chloride,once daily.Based on this, the treatment group added safflower yellow 100mg into 5%glucose injection 250mL and 3 unit insulin by intravenous drip.The period of treatment was three weeks.24h urinary micro-albumin(U-ALB) and urinary albumin excretion rate( UAER) before and after treatment between the two groups were surveyed.Results Before treatment,24 h U-ALB and UAER of the control group were (100.44 ±65.72) mg/L,(117.31 ±68.32)μg/min,which of the treatment group were (123.57 ±63.28) mg/L,(138.57 ±50.82)μg/min.There were no significant differences between the two groups(t=1.098,1.056,all P>0.05).After treatment,24h U -ALB and UAER of the control group were (79.39 ±65.33)mg/L,(92.68 ±67.95)μg/min,which in the treatment group were (71.87 ±60.03)mg/L,(62.52 ± 38.64)μg/min.Statistical differences of 24h U-ALB and UAER were observed in the two groups compared with before treatment(the control group:t=5.903,6.069,the treatment group:t=6.779,12.612,all P<0.05).After treatment, there was no significant difference in 24h U-ALB between the two groups(t=-0.386,P>0.05),while UAER in the treatment group was lower than the control group(t=-2.029,P<0.05).Conclusion Safflower yellow com-bined with kallidinogenase can reduce UAER in early diabetic nephropathy,and what's more,can put off its progress.
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