人类白细胞抗原 B27表达对强直性脊柱炎的诊断价值
Clinical value of HLA-B27 antigen expression in the diagnosis of ankylosing spondylitis
目的:探析人类白细胞抗原(HLA)-B27表达对强直性脊柱炎的诊断价值。方法选择100例强直性脊柱炎患者为观察对象(研究组),选择同时期进行健康检查的健康人100例为对照组,采用 HLA-B27磁珠酵素免疫检验试剂套组对研究组进行新鲜全血定性检测,并对比分析两组的 HLA-B27阳性率,以及HLA-B27表达对强直性脊柱炎的诊断效果。结果研究组 HLA-B27阳性率为73.00%,高于对照组的9.00%,两组差异有统计学意义(χ2=84.66,P <0.01);其中男性患者诊断符合率为90.91%,高于女性患者的72.41%,两者差异有统计学意义(χ2=4.35,P <0.05)。结论HLA-B27表达对强直性脊柱炎患者的临床诊断具有较高应用价值,可提高强直性脊柱炎患者临床诊断效果。
更多Objective To analyze the diagnostic value of human leukocyte antigen(HLA)-B27 expression for ankylosing spondylitis.Methods 100 patients with ankylosing spondylitis were selected as the study group. 100 healthy people were selected as the control group.HLA -B27 beads enzyme immunoassay reagent kits was used to implement qualitative detection of fresh whole blood in the study group,and compared HLA -B27 positive rates of the two groups,as well as the diagnosis value of HLA -B27 antigen expression.Results The HLA -B27 positive rate of the study group was 73.00%,which was higher than 9.00% of the control group,the difference was statistically significant (χ2 =84.66,P <0.01).The diagnosis rate of the male patients was 90.91%,which was higher than 72.41% of the female patients,the difference was statistically significant (χ2 =4.35,P <0.05 ).Conclusion HLA -B27 antigen has a high value for clinical diagnosis of ankylosing spondylitis,which is worthy of promotion.
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