过氧化物还原酶2与多囊卵巢综合征患者发生心血管疾病危险因素的相关性研究
Peroxiredoxin-2 is associated with cardiovascular risk factors in PCOS patients
目的 探讨多囊卵巢综合征(PCOS)患者血浆过氧化物还原酶2(Peroxiredoxin-2)水平及其与此类患者发生心血管危险因素的相关性.方法 收集PCOS患者78例为POCS组,同时选取在同期健康体检者40例为对照组,测定PCOS患者血浆中Peroxiredoxin-2水平、血糖、糖化血红蛋白、胆固醇、甘油三酯等各项生化指标.结果 PCOS组Peroxiredoxin-2的水平大于健康对照组(F=26.03,P<0.05).血浆Peroxiredoxin-2水平与心血管危险因素存在相关性,与收缩压(r=-0.213)、舒张压(r=-0.380)、空腹血糖(r=-0.308)、糖化血红蛋白(r=-0.303)、胆固醇(r=-0.190)、甘油三酯(r=-0.276)、LDL-C(r=-0.484)呈正相关,与CRP(r=0.227)、HDL-C(r=0.355)呈负相关.结论 Peroxiredoxin-2水平的检测可作为评估PCOS患者发生心血管疾病的风险因素的指标.
更多Objective PRDX-2 of the basic level in patients with PCOS,and its correlation with cardiovascular risk factors.Methods Collected 78 cases of PCOS patients for POCS group,at the same time,choose healthy check-up 40 cases for control group.Determination of plasma Peroxiredoxin-2,blood sugar,glycosylated hemoglobin,cholesterol,triglycerides,and other biochemical indicators.Results Peroxiredoxin-2 level in PCOS group are higher than the control group(F=26.03;P<0.05).Peroxiredoxin-2 and cardiovascular risk factors exist correlation,including systolic blood pressure (r=0.213),diastolic blood pressure (r=0.380),fasting blood glucose (r=0.308),glycosylated hemoglobin (r=0.303),cholesterol (r=0.190),triglyceride (r=0.276),LDL-C (r=0.484) were positively correlated,and CRP (r=0.227),HDL-C negative correlation (r=0.355).Conclusion Determination of Peroxiredoxin-2 level can be used as evaluation of patients with PCOS risk factors for cardiovascular disease.
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