柴胡注射液过敏性休克18例回顾性分析
Retrospective analysis of 18 cases of anaphylactic shock induced by bupleurum injection
目的 探讨柴胡注射液致过敏性休克的规律和特点,为临床合理用药提供参考.方法 检索1996-2015年国内医药数据库,收集柴胡注射液致过敏性休克病例报告,进行统计和分析.结果 共检索到柴胡注射液致过敏性休克18例,男女相当,均为肌内注射给药;13例(72.2%)发生在用药后的5 min以内,临床表现以心血管系统和中枢神经系统为主.经积极的抗休克治疗,17例恢复正常,1例死亡.结论 柴胡注射液致过敏性休克临床时有发生,临床用药须重视过敏史询问、用药过程中不良反应的观察,减少用药安全隐患.
更多Objective To investigate the clinic features and regularity of anaphylactic shock induced by bupleurum injection,and to provide reference in clinic tor rational use of bupleurum injection.Methods Checked out the case reports of anaphylactic shock induced by bupleurum injection in the data-bases in China from 1996 to 2015 for statistics and analysis.Results 18 cases of anaphylactic shock were reported and sexual equality,and all were injected intramuscularly;13 cases (72.2%) occurred within 5min and cardiovascular system and central nervous system as the main clinical manifestations.By the active anti-shock therapy,17 cases recovered and 1 case died.Conclusion Allergic shock induced by bupleurum injection happens now and then in clinics,so clinical drug using should pay attention to the history of allergies and medication adverse reactions in the process of observation,in order to reduce drug safety hazards.
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