比伐卢定与肝素用于急性冠状动脉综合征患者急诊经皮冠状动脉介入术的疗效比较
Comparison of the clinical effects of heparin and bivalirudin on percutaneous coronary intervention in patients with acute coronary syndrome
目的 比较伐卢定与肝素分别用于急性冠状动脉综合征患者急诊经皮冠状动脉介入术(PCI)的疗效.方法 将90例急性冠状动脉综合征患者纳入该次研究,按照随机信封法将其分为两组(研究组和参照组),每组45例.研究组患者在PCI术中应用比伐卢定予以辅助治疗,参照组患者则应用普通肝素予以辅助治疗,观察两组纤维蛋白原、活化部分凝血酶时间、凝血酶时间、血浆凝血酶原时间的变化,并分析两组不良事件发生率(心力衰竭、心源性死亡、血小板减少、消化道出血).结果 经过治疗后,在凝血功能指标的对比上,两组差异均无统计学意义(均P>0.05);研究组不良事件发生率为4.44%,参照组不良事件发生率为24.44%,研究组明显低于参照组,且差异有统计学意义(χ2=7.28,P<0.05).结论 在实施急诊经皮冠状动脉介入术时,应用比伐卢定与肝素具有相同的疗效,但比伐卢定具有更可靠的安全性.
更多Objective To compare the efficacy of heparin and bivalirudin in patients with acute coronary syndrome undergoing emergency percutaneous coronary intervention ( PCI ) .Methods A total of 90 patients with acute coronary syndrome were included in this study .They were divided into the study group and control group according to the requirements of random envelope method ,45 cases in each group .The study group received bivalirudin during PCI,the control group was given heparin .The Fbg,APTT,TT and PT were detected in the two groups ,and the inci-dence of adverse reactions ( heart failure , cardiac death , platelet reduction , hemorrhage of digestive tract ) was analyzed.Results After treatment,there were no statistically significant differences between the two groups in various blood coagulation indicators (all P>0.05).The incidence rate of adverse events of the study group was 4.44%, which was significantly lower than 24.44%of the control group ,and the difference was statistically significant (χ2 =7.28,P<0.05).Conclusion Application of heparin and bivalirudin in PCI has similar efficacy ,but the safety of bivalirudin is higher ,which is worthy of clinical promotion .
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