化异汤治疗复发子宫内膜异位症的疗效观察
Clinical effect of Huayi decoction in the treatment of recurrent endometriosis
目的 观察化异汤治疗复发子宫内膜异位症的临床疗效及其对Th1/Th2平衡的影响.方法选择术后复发的子宫内膜异位症患者92例为研究对象,采用随机数字表法分为观察组46例、对照组46例.对照组口服米非司酮,每次12.5 mg,1次/d,连续治疗3个月.观察组服用中药化异汤,连续治疗3个月.观察两组治疗前后血清糖类抗原125(CA125)、干扰素γ(IFN-γ)、白细胞介素4(IL-4)的变化,比较两组临床疗效.结果对照组有效率为78.3%,观察组有效率为91.3%,观察组有效率明显高于对照组(χ2=5.160,P<0.05).对照组治疗前、后血清CA125分别为(103.62±27.45)IU/mL、(55.21±19.23)IU/mL,观察组治疗前、后血清CA125分别为(106.85±22.74)IU/mL、(31.47±12.94)IU/mL,两组治疗后血清CA125均明显降低(t=10.963、14.206,均P<0.01),观察组治疗后血清CA125低于对照组(t=5.038,P<0.05).对照组治疗前IL-4、IFN-γ、IL-4/IFN-γ分别为(22.61±6.72)ng/L、(51.77±8.09)ng/L、(0.41±0.11),治疗后分别为(15.16±5.04)ng/L、(60.39±9.14)ng/L、(0.22±0.07);观察组治疗前IL-4、IFN-γ、IL-4/IFN-γ分别为(23.01±6.71)ng/L、(51.16±7.63)ng/L、(0.42±0.15),治疗后分别为(9.03±3.37)ng/L、(69.91±8.24)ng/L、(0.12±0.05).两组治疗后血清IL-4均明显降低(t=6.0143、8.770,均P<0.01),观察组治疗后IL-4降低更明显(t=3.448,P<0.05);两组治疗后血清IFN-γ均明显升高(t=2.014、2.998,均P<0.05),观察组治疗后IFN-γ升高更明显(t=2.106,P<0.05);两组治疗后血清IL-4/IFN-γ均明显降低(t=5.182、9.062,均P<0.01),观察组治疗后IL-4/IFN-γ降低更明显(t=5.824,P<0.05).结论化异汤可以明显提高子宫内膜异位症复发患者的疗效,并且可以改善Th1/Th2失衡.
更多Objective To study the effect of Huayi decoction in the treatment of recurrent endometriosis ,and its influence on Th1/Th2 balance.Methods 92 patients with recurrent endometriosis were selected as the research subjects.According to the digital table method ,the patients were randomly divided into the observation group and the control group,46 cases in each group.The control group was given mifepristone ,every time 12.5mg,1 time/day, continuously treated for 3 months.The observation group was treated with Huayi decoction for 3 months.The serum carbohydrate antigen 125(CA125),interferon gamma(IFN-γ),interleukin 4(IL-4) were measured before and after treatment.Results After treatment,the effective rate of the control group was 78.3%,which was significantly lower than 91.3% of the observation group (χ2 =5.16,P<0.05).Before and after treatment,the serum CA125 levels of the control group were (103.62 ±27.45) IU/mL,(55.21 ±19.23) IU/mL,respectively.Before and after treatment,the serum CA125 levels of the observation group were (106.85 ±22.74)IU/mL,(31.47 ±12.94)IU/mL, respectively.After treatment,the serum CA125 levels were significantly lower in the two groups (t=10.963,14.206, all P<0.01),and the serum CA125 level in the observation group was significantly lower than that in the control group (t=5.038,P <0.05).The IL -4,IFN -γ,IL -4/IFN -γof the control group before treatment were (22.61 ±6.72) pg/mL,(51.77 ±8.09) pg/mL and (0.41 ±0.11),respectively,which after treatment were (15.16 ±5.04)pg/mL,(60.39 ±9.14)pg/mL and (0.22 ±0.07),respectively.The IL-4,IFN-γ,IL-4/IFN-γof the observation group before treatment were (23.01 ±6.71) pg/mL,(51.16 ±7.63) pg/mL and (0.42 ± 0.15),respectively,which after treatment were (9.03 ±3.37)pg/mL,(69.91 ±8.24)pg/mL and (0.12 ±0.05), respectively.After treatment,the serum IL-4 levels of the two groups were significantly lower (t=6.0143,8.770,all P<0.01),and the decrease of IL -4 level of the observation group was more significant (t=3.448,P<0.05).After treatment,the serum IFN-γlevels were significantly higher in the two groups (t=2.014,2.998,all P<0.05),and the increase of IFN-γlevel of the observation group was more significant (t=2.106,P<0.05).After treatment,the serum IL-4/IFN-γof the two groups were significantly lower (t=5.182,9.062,all P<0.01),and the IL-4/IFN-γdecreased more significantly in the observation group (t=5.824,P<0.05).Conclusion Huayi decoction can significantly improve the postoperative curative effect and improve the imbalance of Th 1/Th2.
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