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体质量管理对肥胖型糖尿病肾病患者血清低氧诱导因子-1α、肿瘤坏死因子-α的影响

Effects of weight management on serum HIF -1αand TNF -αin patients with obese type 2 diabetic nephropathy

摘要:

目的 探讨体质量管理对肥胖型糖尿病肾病患者血清低氧诱导因子-1α(HIF-1α)、肿瘤坏死因子-α(TNF-α)的影响.方法 选取肥胖型糖尿病肾病患者180例,根据体质量管理分为体质量指数(BMI)上升组(BMI较基础值增加≥3%)51例、BMI稳定组(BMI较基础值变化<3%)64例、BMI下降组(BMI较基础值减少3%)65例.采用双抗体夹心酶联免疫法测定血清HIF-1α、TNF-α含量.结果 与BMI下降组比较,BMI上升组和BMI稳定组空腹血糖、糖化血红蛋白、餐后2 h血糖升高(BMI上升组t=10.816、17.839、12.912,BMI稳定组t=6.950、9.878、8.301,均P<0.05);与BMI稳定组比较,BMI上升组空腹血糖、糖化血红蛋白、餐后2 h血糖升高(t=5.298、8.475、5.874,均P<0.05);与BMI下降组比较,BMI上升组和BMI稳定组血肌酐和尿素氮升高(BMI上升组:t=13.477、27.254,BMI稳定组:t=13.820、11.073,均P<0.05);与BMI稳定组比较,BMI上升组血肌酐和尿素氮升高(t=6.502、14.154,均P<0.05);与BMI下降组比较,BMI上升组和BMI稳定组HIF-1α和TNF-α升高(BMI上升组t=30.050、22.963,BMI稳定组t=16.261、16.476,均P<0.05);与BMI稳定组比较,BMI上升组HIF-1α和TNF-α升高(t=17.951、9.601,均P<0.05).结论 BMI上升糖尿病肾病患者血清HIF-1α和TNF-α含量明显增加,通过体质量管理,体质量稳定和体质量下降患者血清HIF-1α和TNF-α含量明显降低.

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Objective To investigate the effect of weight management on serum HIF -1αand tumor necrosis factor α( TNF-α) in patients with obese type 2 diabetic nephropathy .Methods 180 patients with obese diabetic nephropathy were selected .According to weight management , the patients were divided into BMI increased group ( BMI compared with the basic value increased more than or equal to 3%) with 51 cases, BMI stable group ( BMI compared with the basic value changes of <3%) with 64 cases, BMI decreased group ( compared with baseline values BMI reduction of 3%) with 65 cases.The serum contents of HIF -1αand TNF-αwere measured by double antibody sandwich enzyme -linked immunosorbent assay .Results Compared with BMI decreased group ,the fasting blood glucose,glycosylated hemoglobin,postprandial 2h blood glucose in the BMI increased group and BMI stable group were increased (BMI increased group:t=10.816,17.839,12.912,BMI stable group:t=6.950,9.878,8.301, all P<0.05).Compared with the BMI stable group,the fasting blood glucose,glycosylated hemoglobin,postprandial 2h blood glucose in the BMI increased group were increased (t=5.298,8.475,5.874,all P<0.05).Compared with BMI decreased group ,the serum creatinine and blood urea nitrogen in BMI increased group and BMI stable group were increased(BMI increased group:t=13.477,27.254,BMI stable group:t=13.820,11.073,all P<0.05).Compared with the BMI stable group ,the serum creatinine and blood urea nitrogen in the BMI increased group were increased (t=6.502,14.154,all P<0.05).Compared with BMI decreased group ,the HIF-1αand TNF-αlevels of the BMI increased group and BMI stable group were elevated (BMI increased group:t=30.050,22.963,BMI stable group:t=16.261,16.476,all P <0.05).Compared with the BMI stable group,the HIF -1αand TNF -αlevels of BMI ascending group were increased(t=17.951,9.601,all P<0.05).Conclusion The serum levels of HIF -1αand TNF-αin type 2 diabetic nephropathy patients with increased BMI are significantly increased ,and the serum levels of HIF-1αand TNF-αare decreased significantly by weight management .

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