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清热消痰养阴方联合糖皮质激素治疗儿童难治性肺炎支原体肺炎的疗效研究

Effect of heat phlegm and nourishing Yin combined with glucocorticoids in the treatment of refractory Mycoplasma pneumoniae pneumonia in children

摘要:

目的 探讨清热消痰养阴方联合糖皮质激素治疗儿童难治性肺炎支原体肺炎的疗效.方法选取难治性支原体肺炎患儿134例作为研究对象,采用随机数字表法将所有患儿分为对照组和观察组,每组67例.对照组采用氢化可的松治疗,观察组采用清热消痰养阴方联合糖皮质激素治疗.干预1周后,比较两组干预前临床资料及干预后临床症状、体征改善情况和总体治疗效果.结果两组患儿退热时间的差异无统计学意义,观察组咳嗽缓解时间(3.61±1.13)d、肺部啰音吸收时间(6.52±1.90)d、胸腔积液消失时间(7.02±2.10)d,均显著短于对照组的咳嗽缓解时间(4.89±2.18)d(t=2.920,P=0.021)、肺部啰音吸收时间(8.24±2.75)d(t=3.108,P=0.000)、胸腔积液消失时间(9.26±2.38)d(t=5.027,P=0.000);两组患儿白细胞总数、C-反应蛋白、红细胞沉降率差异均无统计学意义,观察组淋巴细胞百分比(55.25±4.91)%,显著高于对照组的(50.16±4.83)%(t=2.597,P=0.037);观察组痊愈率(97.01%)显著高于对照组(83.58%)(t=6.849,P=0.009).结论清热消痰养阴方联合糖皮质激素不仅可以有效地改善患儿的临床症状,提升患儿的淋巴细胞比例,还可以提高总体疗效,值得临床推广.

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Objective To evaluate the clinical efficacy of phlegm and nourishing Yin combined with glucocorticoids in the treatment of refractory Mycoplasma pneumoniae pneumonia in children .Methods 134 children with Mycoplasma pneumonia were divided into control group and observation group according to the random number , 67 cases in each group .The control group were given hydrocortisone ,and the observation group received phlegm and nourishing Yin combined with glucocorticoid .After intervention ,the clinical data and the improvement of the clinical symptoms of the two groups were compared .Results There was no statistically significant difference in antipyretic time between the two groups(P>0.05).The time of cough relief,the absorption time of lung rales,the disappearance time of pleural effusion of the observation group were (3.61 ±1.13) d,(6.52 ±1.90) d and (7.02 ±2.10) d, respectively,which were significantly shorter than those of the control group [(4.89 ±2.18)d,t=2.920,P=0.021;(8.24 ±2.75)d,t=3.108,P=0.000;(9.26 ±2.38)d,t=5.027,P=0.000].There were no statistically signifi-cant differences in the total white blood cell count ,C-reactive protein and erythrocyte sedimentation rate between the two groups(all P>0.05).The percentage of lymphocytes in the observation group [(55.25 ±4.91)%] was signifi-cantly higher than that in the control group [(50.16 ±4.83)%,t=2.597,P=0.037].The effective treatment rate in the observation group was 97.01%,which was significantly higher than 83.58%in the control group (χ26.849,P=0.009).Conclusion Heat phlegm and nourishing Yin combined with glucocorticoid can not only effectively improve the patients'clinical symptoms , improve the proportion of lymphocyte , but also can improve the overall efficacy of children,it is worthy of clinical promotion .

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