阿米替林联合多潘立酮治疗功能性消化不良的临床疗效分析
Clinical efficacy of amitriptyline combined with domperidone in the treatment of functional dyspepsia
目的 观察阿米替林联合多潘立酮治疗功能性消化不良(FD)的临床疗效.方法 选取156例FD患者为研究对象,采用完全随机分配法分为观察组和对照组,各78例.对照组给予多潘立酮治疗,观察组给予阿米替林联合多潘立酮进行治疗.观察两组治疗前后临床症状积分变化与不良反应发生情况,比较其临床疗效.结果 治疗后,观察组总有效率为93.59%,明显高于对照组的76.92%,组间差异有统计学意义(χ2=10.59,P<0.01).两组早饱、餐后腹胀、恶心呕吐、上腹胀痛、嗳气等临床症状积分均明显减少(t观=16.21、14.69、13.84、15.17、42.64,t对=17.54、8.88、16.43、10.98、15.06,均P<0.01),且观察组临床症状改善程度更为显著(t=9.89、9.79、8.47、9.99、18.52,均P<0.01).观察组不良反应发生率16.67%,对照组不良反应发生率23.08%,差异无统计学意义(χ2=1.09,P>0.05),且治疗结束后均自行消失.结论与单独使用多潘立酮相比,阿米替林联合多潘立酮治疗FD患者疗效显著,安全性好,有利于改善其临床症状,提高有效率.
更多Objective To observe and analyze the clinical efficacy of amitriptyline combined with domperidone in the treatment of functional dyspepsia ( FD) .Methods 156 patients with FD were selected as the study subjects , and they were randomly divided into the observation group and the control group ,78 cases in each group .The patients in the control group were treated with domperidone ,and the patients in the observation group were given amitriptyline combined with domperidone .The changes of clinical symptoms scores and the occurrence of adverse reactions were observed before and after treatment in both two groups ,and the clinical curative effect was compared .Results After treatment,the total effective rate of the observation group was 93.59%,which was significantly higher than 76.92%of the control group,and there was significant difference between the two groups (χ2 =10.59,P<0.01).The early satiety,postprandial bloating,nausea and vomiting,epigastric distending pain,belching and other clinical symptoms scores in two groups were significantly reduced ( tobservation group =21.95,33.78,42.12,37.58,42.64, tcontrol group =17.54,8.88,16.43,10.98,15.06,all P<0.01),and the clinical symptoms of the observation group improved more significantly (t=9.89,9.79,8.47,9.99,18.52,all P<0.01).The incidence rate of adverse reactions in the obser-vation group was 16.67%,which in the control group was 23.08%,the difference between the two groups was not statistically significant (χ2 =1.09,P>0.05).After the treatment,the adverse reactions disappeared spontaneously . Conclusion Compared with the use of domperidone alone , the clinical efficacy of amitriptyline combined with domperidone in the treatment of FD patients is significant with good safety ,and is conducive to improve the clinical symptoms of patients ,increase the efficacy and worthy of clinical application .
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