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Collagen for brain repair:therapeutic perspectives

摘要:

Biomaterials have increasingly become a focus of research on neuroprotection and neuroregeneration. Collagen, in terms of brain repair, presents many advantages such as being remarkably biocompatible, biodegradable, versatile and non-toxic. Collagen can be used to form injectable scaffolds and micro/nano spheres in order to: (i) locally release therapeutic factors with the aim of protecting degenerating neurons in neurodegenerative conditions such as Alzheimer's or Parkinson's diseases, (ii) encapsulate stem cells for safe delivery, (iii) encapsulate genetically modified cells to provide a long term source of trophic factors, (iv) fill in the voids from injury to serve as a structural support and provide a permissive microenvironment to promote axonal growth. This mini-review summarizes different applications of collagen biomaterial for central nervous system protection and repair, as well as the future perspectives. Overall, collagen is a promising natural biomaterial with various applications which has the potential to progress the develop-ment of therapeutic strategies in central nervous system injuries and degeneration.

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作者单位: Laboratory of Psychiatry and Experimental Alzheimer's Research, Medical University of Innsbruck, Innsbruck, Austria [1]
期刊: 《中国神经再生研究(英文版)》2018年13卷4期 595-598页 SCIMEDLINEISTICCSCDBP
栏目名称: INVITED REVIEWS
DOI: 10.4103/1673-5374.230273
发布时间: 2018-05-31
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