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菌群移植治疗的实践与思考

Practice and consideration of fecal microbiota transplantation

摘要:

菌群移植(FMT)作为一种革新疗法,为复发性难辨梭菌感染(CDI)的治疗取得突破性的进展。随着生物技术快速的发展,肠道菌群与疾病的联系逐渐得到揭示,FMT在其他传统治疗效果不佳的肠道内外疾病的应用前景也被给予了厚望。但FMT作为新的疗法还存在诸多的未知领域,包括临床供体的筛选、标准化菌液和胶囊的制备、适应证的把握、供体受体的匹配和并发症的防治等,均还在探索阶段。本中心自2012年探索性地开展FMT的治疗,已经治疗逾3 500余例病例,共移植60 000余次。基于大样本的数据和经验,本期对这些问题进行了专刊报道和讨论,并重点推出中国FMT标准化方法学的建立与临床应用,对我国FMT治疗的健康发展定会起到积极的推动作用。

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abstracts:

As an innovative therapy, FMT has made a breakthrough in the treatment of recurrent Clostridium difficile infection (CDI). With the rapid development of biotechnology, the relationship between intestinal microflora and diseases has been gradually eluciated. Great hope has also been given to FMT in other intestinal and extraintestinal diseases with ineffective traditional treatment. However, as a new therapy method, FMT still has many unknown fields, such as the selection of clinical donors, the preparation of standardized bacterial solution and capsule, the selection of indications, the matching of donor and receptor, and the prevention and treatment of complications. Since 2012, our center has carried out treatment research and practice of FMT, so far with more than 60 000 FMTs for more than 3500 cases. Based on large sample data and experience, this special issue reports and discusses the above topics, and focuses on the establishment and clinical application of standardized methodology of FMT, which will undoubtedly play a positive role in promoting the healthy development of FMT treatment in China.

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作者: 李宁 [1]
期刊: 《中华胃肠外科杂志》2020年23卷Z1期 1-4页 MEDLINEISTICPKUCSCD
栏目名称: 述评
DOI: 10.3760/cma.j.cn.441530-20200420-00230
发布时间: 2021-01-11
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