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洗涤菌群移植途径选择的证据与决策

Evidence and decision of the choice of delivery way in washed microbiota transplantation

摘要:

洗涤菌群移植(WMT)作为菌群移植(FMT)的新技术,是FMT发展过程中的新概念。实施WMT的途径包括口服胶囊、鼻空肠管、鼻胃管、胃镜途径、结肠途径经内镜肠道植管术及肛内灌肠等。对于不同适应证或者基于同一适应证的不同研究方案中,因为给入途径等的影响,研究结果差异较大。临床研究设计和临床治疗流程中,影响WMT途径决策的因素主要包括安全性、疗效、成本效果以及患者意愿四方面。本文重点阐述如何在决策过程中整合安全、疗效、成本效果和患者意愿,最终实现医患共满意的目标。

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abstracts:

Washed microbiota transplantation (WMT) is a new concept and technique of fecal microbiota transplantation. The delivery routes of WMT include oral capsule, nasogastric tube, nasojejunal tube, gastroscopy, colonic transendoscopic enteral tubing, and anal enema. The research results among different indications or different designs based on the same indication are quite different, partially because of the influence of WMT delivery route. In the process of clinical research design and clinical practice, there are four aspects that affect the decision-making of WMT delivery route: safety, efficacy, cost-effectiveness, and patients' willingness. This article focuses on how to integrate the four aspects mentioned above in the decision-making process of choosing proper delivery of WMT for the final goal of mutual satisfaction between doctors and patients.

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作者: 张发明 [1] 刘亚飞 [1]
期刊: 《中华胃肠外科杂志》2020年23卷Z1期 45-47页 MEDLINEISTICPKUCSCD
栏目名称: 专题论坛
DOI: 10.3760/cma.j.cn.441530-20200507-00259
发布时间: 2020-11-09
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