线粒体通透性转换孔在脓毒症心肌抑制发生过程中的作用
The role of mitochondrial permeability transition pore in the occurrence of septic myocardial depression
脓毒症是宿主对感染反应失调而导致危及生命的器官功能不全,常合并脓毒症心肌抑制(SMD)。SMD发病机制复杂,尚无特异性治疗手段。线粒体损伤是SMD至关重要的病理基础,位于线粒体膜上的线粒体通透性转换孔(MPTP)对维持线粒体正常结构和功能具有重要作用。现对脓毒症时MPTP的状态改变进行综述,从而揭示MPTP在SMD发生过程中具有的重要意义。
更多Sepsis is defined as life-threatening organ dysfunction caused by a dys-regulated host response to infection and septic myocardial depression (SMD) is a common complication. Pathogenesis of SMD is complicated and there is lack of specific treatment. Mitochondrial damage is an important pathological basis of SMD, and mitochondrial permeability transition pore (MPTP) plays an important role in maintaining the normal structure and function of the mitochondria. The change of MPTP during sepsis is summarized in this review so as to reveal the significant mechanism of MPTP in the occurrence of SMD.
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