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急性肺损伤中肺泡巨噬细胞极化调控机制的研究进展

Research progress on polarization regulation mechanism of alveolar macrophages in acute lung injury

摘要:

急性肺损伤(ALI)是临床常见的危重症,病死率很高。肺泡巨噬细胞(AMs)极化失衡在ALI炎症的发生发展中具有重要作用。研究巨噬细胞极化的调控方式与机制,可以为临床上防治ALI提供更多的理论依据。近年来研究表明,表观遗传学及免疫代谢微环境可调控巨噬细胞极化,影响ALI的免疫炎症反应。本文就巨噬细胞极化、表观遗传学与免疫代谢调控巨噬细胞极化及巨噬细胞极化与ALI之间的关系等相关研究进展进行综述,从而明确调控巨噬细胞极化对ALI的作用和意义,为临床防治ALI提供新思路。

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abstracts:

Acute lung injury (ALI) is a common clinical critical disease, with a high mortality. The imbalance of alveolar macrophage (AMs) polarization plays an important role in the occurrence and development of ALI inflammation. The study of the regulation mode and mechanism of macrophage polarization can provide more theoretical basis for clinical prevention and treatment of ALI. In recent years, it has been found that epigenetics and immune metabolic microenvironment can affect the macrophage polarization and the immune inflammatory response of ALI. In this review, the progress of macrophage polarization, epigenetics and immune metabolism regulating macrophage polarization, the relationship between macrophage polarization and ALI were summarized, so as to clarify the effect and significance of regulating macrophage polarization on ALI, and provide new ideas for the prevention and treatment of ALI in clinic.

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作者: 王盛 [1] 郑莉 [2] 吕欣 [1]
作者单位: 同济大学附属上海市肺科医院麻醉科,上海 200433 [1] 安徽医科大学附属阜阳医院麻醉科,安徽阜阳 236000 [2]
期刊: 《中华危重病急救医学》2020年32卷10期 1269-1272页 MEDLINEISTICPKUCSCD
栏目名称: 综述
DOI: 10.3760/cma.j.cn121430-20200426-00335
发布时间: 2021-01-11
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