2020年突如其来的新型冠状病毒肺炎（新冠肺炎）给重症医学提出了更高的要求，为解决新冠肺炎的许多临床问题，同道们也进行了相关研究。本文拟对这一年新冠肺炎的抗病毒治疗、呼吸支持治疗、免疫调节治疗，以及其他重要的重症问题研究进展进行总结，包括抗菌药物的线粒体损伤与脓毒症的关系，降阶梯治疗的目标和方向，胃肠道紊乱中便秘和出血的药物预防以及信息化时代重症疾病管理的新模式等，以期为重症同仁们的临床和科研工作提供参考。

The epidemic of coronavirus disease 2019 (COVID-19) puts higher demands on critical care medicine. Lots of studies have been conducted to solve COVID-19-related problems. Therefore, we reviewed the annual progress for COVID-19-related issues including antivirals threapies, respiratory support and immunomodulatory therapies and other critical issues, including the effect of antibiotic on mitochondrial damage and its relationship with sepsis, the goal and direction of antimicrobial de-escalation, drug prophylaxis of constipation, bleeding in gastrointestinal disorders and management of critical illness in the informalization era and so on. We hope to provide reference for clinical and scientific research work of the intensivists.