CACNA1C基因多态性与精神分裂症的关联研究
An association study of CACNA1C gene polymorphism with schizophrenia
目的 探讨L型钙离子通道α1C亚基(calcium channel,voltage-dependent,L type,alpha 1C subunit,CACNA1C)基因多态性与精神分裂症的关联.方法 纳入1 432例精神分裂症患者及1 153名正常对照,采用连接酶检测-聚合酶链反应(ligase detection reaction-polymerase chain reaction,LDR-PCR)方法对CAC NA 1C基因rs1006737、rs1024582位点进行基因分型,观察其等位基因及基因型与精神分裂症发病风险的关系.结果 患者组rs1006737位点的基因分布(A、G等位基因频率分别为5.3%、94.7%,AA、AG、GG基因型频率分别为0.2%、10.2%、89.6%)与对照组(A、G等位基因频率分别为4.0%、96.0%,AA、AG、GG基因型频率分别为0.4%、7.4%、92.3%)比较,差异有统计学意义(P<0.05),患者组rs1024582位点的基因分布(A、G等位基因频率分别为4.9%、95.1%,AA、AG、GG基因型频率分别为0.2%、9.3%、90.5%)与对照组(A、G等位基因频率分别为4.0%、96.0%,AA、AG、GG基因型频率分别为0.1%、7.8%、92.1%)比较,差异无统计学意义(P>0.05).rs1006737位点G等位基因(OR=1.332,95%CI=1.016~ 1.746)与精神分裂症相关联(P<0.05).结论 本研究支持在汉族人群中CACNA1C基囚rs1006737位点多态性与精神分裂症相关联.
更多Objective To explore the relationship of calcium channel,voltage-dependent,L type,alpha 1C subunit (CACNA1C) gene polymorphism with schizophrenia.Methods A total of 1 432 patients with schizophrenia and 1 153 healthy controls were selected using Ligase Detection Reaction-Polymerase Chain Reaction(LDR-PCR) to analyze the genotypes of CACNA1C gene (rs1006737 and rs1024582).Results The allelic and genotypic distributions in rs1006737 between patients with schizophrenia (A,G allele:5.3%,94.7%;A/A,A/G,G/G genotypes:0.2%,10.2%,89.6%) and healthy controls (A,G allele:4.0%,96.0%;A/A,A/G,G/G genotypes:0.4%,7.4%,92.3%) had statistically significance after analysis (P<0.05).The allelic and genotypic distributions in rs1024582 between patients with schizophrenia (A,G allele:4.9%,95.1%;A/A,A/G,G/G genotypes:0.2%,9.3%,90.5%) and healthy controls (A,G allele:4.0%,96.0%;A/A,A/G,G/G genotypes:0.1%,7.8%,92.1%) did not have statistically significance after analysis (P>0.05).The G allele of rs1006737 (OR=1.332,95%CI=1.016-1.746) was associated with the risk of schizophrenia(P< 0.05).Conclusion This research supports that CACNA1C gene rs1006737 polymorphism is associated with schizophrenia in Han Chinese.
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