磁共振弥散张量成像在弥漫性轴索损伤评估中的价值
The value of MR diffusion tensor imaging in evaluating diffuse axonal injury
目的 探讨磁共振弥散张量成像(DTI)在弥漫性轴索损伤(DAI)评估中的价值.方法 回顾性分析DAI患者(DAI组)及健康志愿者(正常对照组)DTI影像资料,测量胼胝体等六个脑区的各向异性分数(FA)值并检测血清髓鞘碱性蛋白(MBP)水平.结果 与对照组比较,DAI组患者胼胝体膝部、胼胝体压部、内囊前肢、内囊后肢及丘脑FA值均减低(P <0.01,P<0.05).各组FA值与血清MBP水平呈负相关(r=-0.755,P=0.001).结论 DTI能够无创、客观反映DAI患者的脑白质纤维束损伤情况,对于预后及疗效评估具有重要临床意义.
更多Objective To investigate the clinical value of MR diffusion tensor imaging (DTI) in evaluating diffuse axonal injury (DAI).Methods The DTI imaging data of DAI patients and healthy volunteers were analyzed retrospectively.Fractional anisotropy (FA) values were measured in corpus callosum,etc.The serum myelin basic protein (MBP) was detected.Results Compared to the control group,the FA values were lower in genu of corpus callosum,splenium of corpus callosum,anterior limb of the internal capsule,posterior limb of the internal capsule and thalamus in DAI group (P < 0.01,P < 0.05).The mean FA values of two groups were negatively correlated with serum MBP levels (r =-0.755,P =0.001).Conclusions DTI can noninvasively reflect the damages of white matter fibers in DAI patients,and it has importantly clinical significance in evaluating prognosis and therapeutic effect of DAI patients.
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