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射频消融术后心房颤动复发患者血清超敏C反应蛋白与白细胞介素6水平的表达及意义

Expression and clinical significance of high-sensitivity C-reactive protein and interleukin-6 in patients with recurrence of atrial fibrillation after radiofrequency catheter ablation

摘要:

目的 探讨射频消融术后心房颤动复发患者血清超敏C-反应蛋白(hs-CRP)与白细胞介素-6(IL-6)水平的表达及意义.方法 对我院2011年1月至2015年12月收治的行射频消融术治疗的97例阵发性心房颤动患者的临床资料进行回顾性分析,按射频消融术后半年患者是否复发分为复发组和成功组.检测射频消融术前患者的血清hs-CRP、IL-6浓度,并与同期健康查体者进行对照比较(对照组).采用Logistic回归分析法分析射频消融术后心房颤动复发的危险因素.结果 心房纤颤组患者血清hs-CRP、IL-6浓度[(4.6±1.2)、(0.19±0.05) mg/L]均高于对照组[(2.0±0.3)、(0.10±0.03) mg/L],两组比较差异均有统计学意义(P值分别为0.037、0.046).术后6个月复发患者29例(29.9%,29/97).根据心房纤颤复发与否将97例患者分为复发组(29例)和成功组(68例),复发组患者血清hs-CRP、IL-6浓度分别为(5.61±2.30)、(0.30±0.07) mg/L,成功组分别为(3.29±1.62)、(0.15±0.06) mg/L,两组比较差异均有统计学意义(P值分别为0.047、0.036).Logistic回归分析结果表明:左心室前后径(OR值为2.073,95%CI:1.078~4.126,P=0.031)、血清hs-CRP浓度(OR值为1.943,95%CI:1.025~3.698,P=0.042)、血清IL-6浓度(OR值为2.071,95%CI:1.089~10.101,P=0.027)均为射频消融术后心房颤动复发的危险因素.结论 炎症因子参与了心房纤颤的发生和维持,血清hs-CRP、IL-6水平与心房颤动复发有关,可作为术后心房颤动复发的独立预测因素.

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abstracts:

Objective To investigate the expression and clinical significance of high-sensitivity C-reactive protein(hs-CRP) and interleukin-6 (IL-6) in patients with recurrence of atrial fibrillation(AF) after radiofrequency catheter ablation.Methods Retrospective analysis was made among a total of ninety-seven cases of paroxysmal atrial fibrillation treated by radiofrequency catheter ablation in Chaoyang Central Hospital from January 2011 to December 2015.The patients were divided into recurrent group and successful group,depending on whether they had recurrence in six months after radiofrequency catheter ablation.The concentration of the patients'' serum hs-CRP and IL-6 before radiofrequency catheter ablation were detected and compared with those of the healthy subjects (control group) during the same period.Logistic regression analysis was used to analyze the risk factors in atrial fibrillation recurrence after radiofrequency catheter ablation.Results The levels of serum hs-CRP was (4.6±1.2) mg/L and IL-6 was(0.19±0.05) mg/L in the recurrent group,higher than those in the control group ((2.0±0.3) mg/L,(0.10±0.03) mg/L).The differences between the two groups were statistically significant (P=0.037,0.046).According to the atrial fibrillation recurrence,97 patients were divided into recurrent group (29 cases) and successful group (68 cases).The levels of serum hs-CRP and IL-6 in the recurrent group were (5.61±2.30) mg/L,(0.30±0.07) mg/L,respectively,while the data of the successful group were (3.29±1.62) mg/L,(0.15±0.06) mg/L,respectively.There were significant differences between the two groups (P=0.047,0.036).Logistic regression analysis showed that the left ventricular anterior and posterior diameter (OR=2.073,95%CI:1.078~4.126,P=0.031),levels of serum hs-CRP (OR=1.943,95%CI:1.025-3.698,P=0.042) and serum IL-6 (OR=2.071,95%CI:1.089-10.101,P=0.027) were all risk factors in atrial fibrillation recurrence after radiofrequency catheter ablation.Conclusions Inflammatory factors might be involved in the occurrence and maintenance of atrial fibrillation.The expression levels of serum hs-CRP and IL-6 are related to the recurrence of AF,which could be independent predictors of postoperative atrial fibrillation recurrence.

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