关节软骨损伤的治疗和研究进展
Treatment and Research Progress of Articular cartilage injury in HT3SS
关节软骨损伤是发病率和患病率非常高的骨科疾病之一,尤其是在中老年群体中.关节软骨损伤造成关节软骨的退行性病变,如骨关节炎,可以导致残疾、关节运动期间的疼痛以及骨关节的变形.骨关节炎的患病率占全球人口总数的10%~12%,是较为常见的疾病,年龄>65岁的老年人,骨关节炎患病率已经上升至49. 7%[世界卫生组织(WHO)2010年统计数据显示],随着社会老龄化和肥胖等不良因素的不断发展,这些数字将会持续上升.现在已知的是骨关节炎与衰老、创伤、遗传易感性、肥胖和炎症有关,但是具体的病因尚未完全明确,这导致临床上对骨关节炎的治疗仍然存在很多障碍.目前该领域的大多数临床和研究工作都集中在恢复软骨的创伤性损伤,现总结并讨论了软骨缺损修复方法,以及今后科研工作的热点和方向.
更多Objective Articular cartilage injury is one of the most common orthopedic diseases with high morbidity and morbidity,especially in the elderly. Articular cartilage injury causes degenerative changes of articular cartilage, such as osteoarthritis, which can lead to disability, pain during joint movement and deformation of bone and joint. The prevalence of osteoarthritis accounts for 10% ~12% of the total population in the world. It is a common disease. The prevalence of osteoarthritis has increased to 49. 7% for the elderly aged over 65 years old ( Statistics of the World Health Organization ( who) in 2010 show that with the development of social aging and obesity and other adverse factors,these figures will continue to rise. It is known that osteoarthritis is related to aging,trauma,genetic susceptibility,obesity and inflammation,but the specific cause of osteoarthritis has not been fully identified, which leads to many obstacles in clinical treatment of osteoarthritis. At present,most of the clinical and research work in this field is focused on the restoration of cartilage trauma. In this review, we summarize and discuss the methods of cartilage defect repair,as well as the hot spots and directions of future research work.
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