摘要目的探讨脾脏非霍奇金淋巴瘤（NHL）的临床病理特征及其与瘤细胞属性的关系。方法复习19例NHL的临床病理资料、进行随访、并用SP法行CD45RO 、CD20及髓过氧化物酶等免疫组织化学染色，对CD45RO阳性的病例加作CD8、CD56、TIA-1、CD68免疫表型检测和EB ER原位杂交。结果（1）19例均有脾脏肿大，其中52.6% (10/19) 有脾脏占位病变，（2）7 3.7％ (14/19)为B细胞性，滤泡型5例，弥漫型9例；中心母细胞性8例，中心母细胞/中心细胞性3例，小细胞性4例；10例原发脾脏NHL均为B细胞性；（3）26.3% (5/19)为外周T细胞性，大细胞性4例，小细胞性1例；TIA-1阳性3例，其中CD8阳性和CD56阳性各1例，且均为EBER1/2阳性, 余1例为CD8、CD56、EBER均阴性；均为继发脾脏NHL；（4）73.7% (1 4/19)有随访，9例生存者中有8例为原发脾脏NHL，生存时间为8个月～10年不等；5例死亡病例均为继发脾脏NHL，生存时间为2～6个月不等。结论脾脏NHL 的临床病理表现与瘤细胞的属性有一定关系，原发脾脏NHL的预后明显优于继发脾脏NHL，对原发脾脏NHL的诊断应从严把握。

abstractsObjective　 To investigate the relationship between clinicopathologic features and immunophenotypes in non-Hodgkin's lymphoma (NHL) of the spleen. Methods　 Clinicopathologic analysis and follow up; immunohistologic staining by SP method and EBER in situ hybridization. Results　 (1) Splenomegaly was found in al l 19 cases of spleen NHL, 10 of the 19 (52.6%) cases had masses or a mass in the ir enlarged spleen; (2) 14 of the 19 (73.7%) cases were of B-cell type (includi n g 5 cases of follicular type and 9 cases of diffuse type) ,in which 8 cases were centroblastic, 3 of centroblast/centrocyte and 4 cases of s mall lymphocyte types; all 10 cases of primary splenic lymphomas (PSL) were B-c ell type ; (3) 5 of the 19 cases (26.3%) had peripheral T-cell origin, including 4 cases of large cell type and 1 case of small cell type; of the 3 TIA-1 positive cases , 2 we re also positive for EBER 1/2 (one CD 8+ and another CD56+), the remaining case was CD8-, CD56-, EBER1/2-; all 5 cases were secondary NHL of the spleen; (4) Fol lo w up data were obtained for 14/19 cases (73.7%). 8 of 9 surviving cases were pri m ary NHL. The range of survival period varied from 8 to 10 years. All 5 deceased cases had secondary NHL and their survival period was 2 to 6 months. Conclusions　 Some relationship exists between the clinicopathology and origin of the tumor c ells in splenic NHL, the prognosis of primary NHL is better than that of the sec ondary NHL and the diagnosis of primary NHL should be made with discretion.