摘要目的探讨淋巴结细胞毒性自然杀伤(NK/T)细胞淋巴瘤的临床病理学特征。方法对5例淋巴结细胞毒性NK/T细胞淋巴瘤作临床病理观察及随访、用LSAB法做免疫表型分析（CD45RO、CD 8、CD56、CD30、CD20、TIA-1）及EBER1/2原位杂交检测。结果淋巴结细胞毒性NK/T细胞淋巴瘤的病理组织学特点为：(1)淋巴结结构明显破坏并被瘤细胞所取代； (2) 瘤细胞呈多形性；（3）多数肿瘤细胞表达淋巴细胞分化抗原。5例中CD45RO阳性的有4例，其中3例瘤细胞同时呈CD56阳性；1例为无标记细胞性；所有病例的TIA-1和EBER均为阳性。结论淋巴结细胞毒性NK/T细胞淋巴瘤有特征性的形态改变和免疫表型,提示肿瘤进展及预后不良。

abstractsObjective　 To investigate the clinicopathologic features of cytotoxi c natural killer (NK)/T-cell lymphomas of the lymph nodes. Methods　 Clinicopatho logic observations and follow up on 5 cases of cytotoxic NK/T-cell lymphomas of the lymph nodes, immunohistochemical staining for CD45RO,CD8,CD56,CD30,CD20,TIA -1 and in situ hybridization for EBER1/2 were performed. Results　 (1) The clinico pathologic features of cytotoxic NK-T-cell lymphomas of the lymph nodes were s um marized; (2) The tumor cells were positive for CD45RO in 4 of the 5 cases, in wh ich 3 cases were also positive for CD56. One case was of null cell type. The tum or cells were positive for TIA-1 and EBER1/2 in all 5 cases. Conclusions　 The clin icopathological features and special immunophenotypes of cytotoxic NK/T-cell ly m phomas of the lymph nodes were present in all 5 cases. Clinically, this entity t ends to be an aggressive process with poor prognosis.