摘要目的 研讨细小病毒B19感染对新生儿的危害和病理诊断.方法 对临床疑围产期和宫内B19感染的3例新生儿或死产胎儿和2例胎盘分别进行尸检和活检.结果 在1例骨髓造血组织、肝和脾的髓外造血灶和肺血管内,1例脾和肝髓外造血灶,1例脾髓外造血灶,以及2例胎盘绒毛血管中的幼红细胞中找到诊断性的核内包涵体.1例新生儿有严重贫血而死亡,2例死胎有胎儿水肿,1例胎盘活检病例伴死产,1例胎盘活检病例因胎儿畸形而引产.结论 细小病毒B19感染引起的重度贫血、胎儿水肿和诱发噬血细胞综合征等可导致新生儿死亡,病理诊断的关键为在幼红细胞中找到诊断性核内包涵体,可为诊断B19感染提供重要的依据.

abstractsObjective To characterize the risks and histopathologieal features of parvovims B19 infection of infants in perinatal period.Methods Routine pathological examination was performed on 1 neonate,2 dead fetuses and 2 placentas using either autopsy or biopsy materials.Results The diagnostic intranuclear inclusions were found in erythroblagts in the bone marrow,liver,spleen and lungs in one case, in the spleen and liver in one case, in the spleen in one case, and in the placentas in two cages.Conclusions Severe hemolytic anemia or fetal hydrop or hemophagoeytosis caused by the infection of parvovirus B19 can lead to death of infected neonates and fetus.Pathological confirmation of parvovirus B19 infection relies on the identification of erythroblasts containing the diagnostic intranuelear inclusions.