摘要目的 研究上皮性钙黏附蛋白(E-cadherin,简称E-cad)、p120catenin(简称p120)和34βE12在乳腺浸润性小叶癌(ILC)中的表达及其诊断意义.方法 收集北京军区总医院病理科2000至2010年间主要依据形态学诊断过的ILC 81例,其中单纯性67例,导管-小叶混合性14例,分别进行免疫组织化学(MaxVision法)E-cad、p120和34βE12染色,综合形态学及免疫组织化学染色结果重新确诊,分析前后病理诊断的差异及三项指标在ILC中的表达情况.结果 81例中64例确诊为ILC,其中单纯性61例,混合性3例.在61例单纯性ILC中,54例表现为E-cad阴性、p120胞质阳性；1例E-cad阴性,p120不典型表达；3例E-cad膜表达,同时p120胞质表达；3例E-cad与p120同时具有不典型表达；61例中有52例表达34βE12.3例混合性ILC中,其中的ILC部分免疫表型为p120胞质阳性,E-cad阴性2例,不典型表达1例；34βE12均阳性.结论 ILC是病理诊断的难点,联合应用E-cad与p120免疫组织化学染色可有效辅助诊断；对具有小叶癌形态特征的浸润性导管癌,需要更深入的研究.

abstractsObjective To investigate expressions of E-cadherin (E-cad).p12Ocatenin (p120),34βE12 in invasive lobular carcinomas of the breast and their roles of diagnoses.Methods The 81 cases of ILC,including 67 cases of pure type and 14 cases of ductal-lobular mixed type,which had been diagnosed in our department were collected and i mmunohistochemistry of E-cad,p120 and 34βE12 were performed.All the cases were diagnosed again according to morphology and immunophenotypes ( MaxVision method),and difference of diagnoses and expressions of the three indexes were analysed.Results Sixty four of 81 cases were permantly diagnosed of ILC.In the 61 cases of pure type,54 cases displayed E-cad negative and p120 cytoplastic positive,1 case displayed E-cad negative and p120 atypical positive,3 cases displayed E-cad membrane positive and p120 cytoplastic positive,and 3 cases displayed both atypical positive.Fifty two of 61 cases displayed 34βE12 positive.The 3 cases of mixed type displayed p120 cytoplastic positive,and 2 cases displayed E-cad negative and 1 case displayed atypical positive.All the 3 cases displayed 343E12 positive.Conclusions The diagnosis of ILC is one of the most difficult problems in breast pathology,and combination of E-cad and p120 immunostaining is an effective method for assistance.It needs further studies for invasive ductal carcinomas with morphological features of lobular carcinomas.