摘要目的 探讨微管相关蛋白-2(MAP-2)在肺小细胞癌中的诊断价值.方法 应用免疫组织化学EnVision法检测240例2008至2011年间收集的肺小细胞癌中突触素、嗜铬粒素A(CgA)、CD56、MAP-2及甲状腺转录因子1(TTF-1)的表达.结果 MAP-2在肺小细胞癌中的阳性率为95.8％ (230/240),明显高于突触素、CgA及CD56的阳性率[分别是57.1％ (137/240),38.8％(93/240),89.2％ (214/240)].其敏感性(99.1％)及准确性(95.4％)明显高于突触素(58.3％,42.5％) 、CgA(39.9％,42.5％)及CD56(91.5％,87.9％).结论 MAP-2是敏感性及准确性高的神经内分泌标志抗体,值得在肺小细胞癌诊断中推广应用.

abstractsObjective To investigate the diagnostic value of microtubule-associated protein-2 (MAP-2) in biopsy of small cell lung carcinoma (SCLC).Methods Immunohistochemical technique was applied to detect the expression of synaptophysin (Syn),chromogranin A (CgA),CD56,MAP-2 and TTF-1 in 240 cases of SCLC from 2008 to 2011 in this hospital.Results The positive rate of MAP-2 expression in SCLC was 95.8％ (230/240),which was much higher than that of Syn (57.1％,137/240),CgA (38.8％,93/240) and CD56 (89.2％,214/240).The sensitivity and accuracy of MAP-2 (99.1％,95.4％) expression were also higher than those of Syn (58.3％,42.5％),CgA (39.9％,42.5％) and CD56 (91.5％,87.9％).Conclusions MAP-2 is a new neuroendocrine marker with higher sensitivity and accuracy,and thus recommended to be added to the immunohistochemical panel for the diagnosis of SCLC.