摘要目的 对已发表的文献采用meta分析方法系统评估谷胱甘肽-S-转移酶(GST) M1基因多态性与中国人群乳腺癌的易感性.方法 计算机检索Pubmed、Embase、Cochrane library、中国知网(CNKI)、维普(VIP)、万方数据及中国生物医学文献数据库(CBD),收集关于GSTM1基因多态性与中国人群乳腺癌易感性的相关研究,按纳入与排除标准筛选文献、提取资料并评价纳入研究的质量后,采用RevMan 5.2、Stata 12.0软件进行meta分析,计算合并OR值及其95％ CI,并进行发表偏倚评估及敏感性分析.结果 共纳入15项研究,累积病例5 176例,对照5 890例.meta分析结果显示,中国人群中GSTM1基因缺失型个体较正常型个体乳腺癌发病风险明显增高(OR=1.34,95％ CI=1.12 ～1.60,P=0.002);按地区进行亚组分析结果显示,中国南方及北方人群GSTM1基因缺失型个体乳腺癌发病风险均较正常型高(南方人群:OR=1.14,95％CI=1.01～1.28,P=0.03;北方人群:OR =2.65,95％ CI =2.04 ～3.34,P＜0.01).结论 GSTM1基因多态性与中国人群乳腺癌易感性相关,GSTM1基因缺失可能增加乳腺癌的发病风险.

abstractsObjective To evaluate the published data on association between present/null polymorphism of glutathione S-transferase M1 (GSTM1) and breast cancer risk in Chinese population in order to abttain a more precise and comprehensive estimation of the relationship.Methods A meta-analysis was performed to investigate the association between GSTM1 polymorphism and susceptibility to breast cancer in Chinese population by searching Pubmed,Embase,Cochrane library,CNKI,VIP,Wanfang and CBD database.The data were screened according to the inclusion and exclusion criteria,and extracted,and the quality of included studies was evaluated.The pooled odds ratios (OR) with 95％ confidence intervals (95％CI) were calculated using RevMan 5.2 and Stata 12.0 software.Publication bias and sensitivity analysis were also assessed.Results A total of 15 case-control studies involving 5 176 cases and 5 890 controls were included in the meta-analysis.The results showed that individuals with GSTM1 null genotype harbored a significantly increased risk of breast cancer compared to that with GSTM1 non-null genotype in Chinese population (OR =1.34,95％ CI =1.12-1.60,P =0.002).The subgroup analysis by region revealed that the individuals with GSTM1 null genotype were significantly associated with an increased risk of breast cancer in southern and northern China populations (southern:OR =1.14,95％ CI =1.01-1.28,P =0.03; northern:OR=2.65,95％CI=2.04-3.34,P＜0.01).Conclusion The current meta-analysis demonstrates that the GSTM1 polymorphism is significantly associated with susceptibility to breast cancer in Chinese population,and the GSTM1-deficit may increase the risk of breast cancer.