摘要目的：探讨球形幽门螺杆菌（ HP）感染的组织学检测方法及单纯球形HP感染的临床病理学意义。方法采用HE染色、HP检测试剂盒（银染法）及免疫组织化学SP法，检测171例胃黏膜活检标本，观察不同形态HP在黏膜中的定植数量及部位，同时观察胃黏膜病变的相关病理学指标。结果单纯球形 HP 感染组的黏膜糜烂率及炎症活动率分别为36.0％（9/25）和44.0％（11/25），均高于HP阴性者（阳性率分别为13.5％，10/74；24.3％，18/74），但低于同时伴有螺旋状HP感染者（阳性率分别为72.1％，49/68；79.4％，54/68），间质淋巴细胞数量及炎症严重程度均高于HP阴性组，但低于伴有螺旋状HP感染组。结论球形HP具有致病性，单纯球形HP感染时黏膜炎性反应要弱于螺旋状HP，该类病例应成为HP临床研究重点。

abstractsObjective To study the detection method of coccoid helicobacter pylori ( HP) and to investigate the significance of pure coccoid HP infection of gastric mucous membrane.Methods A total of 171 gastric biopsy specimens were reviewed by HE stain ,and the presence , density and tissue distribution of HP were investigated by sliver stain and immunohistochemistry ( S-P method ).Results The rates of mucosal erosion and active inflammation with the presence of pure coccoid HP infection were 36.0%(9/25) and 44.0%(11/25), respectively, both higher than those without HP infection (13.5%,10/74;24.3%, 18/74), while lower than those infected with spiral HP (72.1%,49/68;79.4%,54/68).The quantity of interstitial lymphocyte and inflammation severity were also higher than those without HP infection , while lower than those with spiral HP infection.Conclusions Pure coccoid HP causes human gastritis , similar to that of spiral HP infection but at a lesser degree.Further studies are important to confirm its clinical significance.