摘要目的 统计中山大学肿瘤防治中心4年间诊断的所有成熟T和自然杀伤(NK)细胞淋巴瘤病例,分析其不同类型的构成比,研究各类型成熟T和NK细胞淋巴瘤CD30表达情况,为抗CD30抗体药物在成熟T和NK细胞淋巴瘤的应用提供参考数据.方法 选取2009年9月1日至2013年8月31日4年间中山大学肿瘤防治中心诊断的所有成熟T和NK细胞淋巴瘤,统计分析各类型淋巴瘤的发病情况.抽调其中存档的164例成熟T和NK细胞淋巴瘤患者的病理蜡块进行免疫组织化学EnVision法检测其CD30的表达.结果 4年间共诊断成熟T和NK细胞淋巴瘤625例.最常见为结外鼻型NK/T细胞淋巴瘤(ENKTL),共319例(51.0％),其余常见病例分别为血管免疫母细胞性T细胞淋巴瘤(AITL) 119例(19.0％)、非特指型外周T细胞淋巴瘤(PTCL-NOS)81例(13.0％)、间变性大细胞淋巴瘤(ALCL)[包括系统性ALCL 48例(7.7％)及原发皮肤ALCL 11例(1.8％)].除ALCL外,在本院存档的164例病例中,CD30阳性率最高的是NK/T细胞淋巴瘤,阳性率为62.1％(41/66).16例PTCL-NOS仅1例阳性,其余28例AITL及其他少见类型的淋巴瘤无1例阳性.结论 中山大学肿瘤防治中心收集的成熟T和NK细胞淋巴瘤不同类型的发病情况各异.CD30在多种成熟T和NK细胞淋巴瘤中均有不同程度表达,除间变性大细胞淋巴瘤,NK/T细胞淋巴瘤的阳性表达率最高,有望成为抗CD30抗体药物治疗的候选病种.

abstractsObjective To investigate the frequency of different types of mature T-and NK-cell lymphomas diagnosed in a 4-year period at Sun Yat-sen University Cancer Center,and to study baseline CD30 for potential anti-CD30 targeted therapy in mature T-and NK-cell lymphoma.Methods All cases of mature T-and NK-cell lymphoma diagnosed at Sun Yat-sen University Cancer Center from September 1,2009 to August 31,2013,were reviewed.Paraffin-blocks of available 164 consecutive cases were stained for CD30 immunohistochemistry using EnVision protocol.Results A total of 625 cases of mature T-and NK-cell lymphomas were diagnosed and the most common type was extranodal NK/T cell lymphoma (ENKTL),nasal type 319 (51.0％) cases,followed by angioimmunoblastic T-cell lymphoma (AITL) (119 cases,19.0％),peripheral T-cell lymphoma,not otherwise specified (PTCL-NOS) (81 cases,13.0％),and anaplastic large-cell lymphoma (ALCL),including 48 cases (7.7％) of systematic ALCL and 11 cases(1.8％) of primary cutaneous ALCL.Besides ALCL,ENKTL had the highest expression rate of CD30 among the 164 cases,with positivity observed in 41 cases (62.1％,41/66).Only 1 case of PTCL-NOS was CD30 positive.CD30 was not expressed in all 28 cases of AITL and other rare types of mature T-and NK-cell lymphoma.Conclusions The frequency of different types of mature T-and NK-cell lymphoma encountered at Sun Yat-sen University Cancer Center was similar to that seen in other areas of China and other Asia countries.CD30 expression is different among several types of mature T-and NK-cell lymphoma.In addition to ALCL,ENKTL has the highest expression rate of CD30,which may be a candidate disease for anti-CD30 targeted therapy.