摘要目的：研究肺非黏液型原位腺癌（NMAIS）与非特殊型浸润性腺癌中突变p53蛋白过表达情况，比较其在肺NMAIS与非特殊型浸润性腺癌中的表达差异。方法用免疫组织化学方法检测17例肺NMAIS与70例肺非特殊型浸润性腺癌突变p53蛋白过表达情况。结果突变p53蛋白过表达在肺NMAIS中为0／17，在肺非特殊型浸润性腺癌为37／70（52．9％），两者之间比较差异有统计学意义（ P＝0．000）。结论突变p53蛋白过表达在部分肺NMAIS进展为浸润性肺腺癌中可能起着重要的作用。

abstractsObjective To study the over-expression of mutant p53 protein in non-mucinous adenocarcinoma in-situ ( NMAIS ) and invasive adenocarcinoma, NOS of lung. Methods Immunohistochemical study for p53 protein was performed on 17 cases of NMAIS and 70 cases of invasive adenocarcinoma, NOS of lung.The difference in p53 over-expression between the two tumor subtypes was analyzed.Results The over-expression of mutant p53 protein was observed in 0 case (0%) of NMAIS and 37 cases (52.9%) of invasive adenocarcinoma, NOS of lung.The difference was of statistical significance (P =0.000).Conclusion Mutant p53 protein over-expression may play a role in the progression of NMAIS to invasive adenocarcinoma, NOS.