摘要目的：检测HGAL及LMO2在滤泡性淋巴瘤（ FL）中的表达情况，并与传统的生发中心标志物CD10、bcl－6相比较，探讨前者在临床病理诊断中的应用价值及其意义。方法收集广东省人民医院病理科63例确诊为FL的病例，采用免疫组织化学的方法，研究HGAL、LMO2、CD10及bcl－6的表达情况并进行统计学分析。结果 HGAL、LMO2、CD10和bcl－6的总体表达率分别为98．4％（62／63）、82．5％（52／63）、82．5％（52／63）和87．3％（55／63）；HGAL表达率高于LMO2、CD10及bcl－6，但差异无统计学意义（ P ＞0．05）。 HGAL、LMO2、bcl－6在各级 FL 表达差异均无统计学意义（P＞0．05）；CD10表达在FL1～3A与FL3B之间差异有统计学意义（P ＜0．01）。结论 HGAL 及LMO2，特别是HGAL可作为滤泡中心细胞有用的辅助诊断标志物，尤其对高级别FL的诊断作用可能更大。

abstractsObjective To evaluate the diagnostic value of HGAL and LMO2 expression and compare with CD10 and bcl-6 in follicular lymphoma ( FL) .Methods 63 cases of FL were collected from Guangdong General Hospital. The expression of HGAL, LMO2, CD10 and bcl-6 was assessed by immunohistochemistry.Results The expression rates of HGAL, LMO2, CD10 and bcl-6 were 98.4%(62/63), 82.5%(52/63), 82.5%(52/63) and 87.3%(55/63), respectively.The expression rate of HGAL was higher than those of LMO2, CD10 and bcl-6, but the differences were not significant ( P >0.05).There was no significant difference in HGAL, LMO2 and bcl-6 expression among FL1, FL2 and FL3 cases.The CD10 expression rate of FL1-3A cases was significantly higher than that of FL3B cases ( P<0.01) .Conclusions HGAL and LMO2, especially HGAL, can be used in FL particularly high grade FL as useful germinal center marker.