摘要目的：筛查及分析Vav3基因位点多态性与前列腺癌发生、发展的相关性及其临床意义。方法收集并建立2008至2012年间1015例前列腺癌患者及1068例无瘤健康对照，通过NCBI dbSNP （ http：／／www.ncbi.nlm.nih.gov／projects／SNP ）以及 SNPinfo （ http：／／snpinfo.niehs.nih.gov／snpfunc.htm）数据库，分析并筛选Vav3单核苷酸多态位点，运用Logistic回归分析所选位点与前列腺癌发病的相关性，并进行位点多态性与前列腺癌不同临床病理参数、生化复发相关性分析。结果Vav3 rs12410676 G＞A与前列腺癌的发生呈负相关[相加模型OR＝0.80（0.69～0.93）， P＝0.003；显性模型OR＝0.81（0.68～0.97）， P＝0.022；隐性模型OR＝0.54（0.36～0.82）， P＝0.004]。同时Vav3 rs8676 G＞A与rs12410676 G＞A的联合效应与前列腺癌的发生存在负相关，随着变异位点数量的增加患前列腺癌的风险越小（ P＜0.05）。在分层分析中，相对于Vav3 rs12410676 GG组，携带AA／AG的人群在体质量指数≤25 kg／m2组，或吸烟组，或Gleason 评分≥7分（4＋3），或高侵袭性前列腺癌中都具有保护作用。运用假阳性报告概率法对获得的结果进行了假阳性分析，结果发现在不同的先验概率（0.25，0.1，0.01）的情况下，上述结果具备不同的统计学效能。结论 Vav3基因位点多态性与中国前列腺癌的发生具有一定的相关性，但相关效应较低，尚需在大样本量、多中心、不同种族的前列腺癌研究中加以验证。

abstractsObjective To study the associations between genetic variations of Vav 3 gene and prostate cancer susceptibility.Methods Data were collected in a hospital-based and case-control study of 1 015 prostate cancer cases and 1 068 cancer-free controls collecting from a period of time between 2008 and 2012.Based on the online database , NCBI dbSNP ( http://www.ncbi.nlm.nih.gov/projects/SNP ) and SNPinfo ( http://snpinfo.niehs.nih.gov/snpfunc.htm ) . Functional single nucleotide polymorphisms (SNPs) of Vav3 were screened and genotyped , and assessed their associations with risk of prostate cancer by using logistic regression analysis.Furthermore, the associations between SNPs of Vav 3 and some clinicopathological parameters were evaluated.Results Among the two SNPs investigated , only Vav3 rs12410676 G>A was associated with decreased prostate cancer risk [additive model, OR=0.80 (0.69-0.93), P=0.003;dominant model, OR=0.81 (0.68-0.97), P=0.022;recessive model, OR=0.54 (0.36-0.82), P=0.004].The combined effect of Vav3 rs8676 G>A and rs12410676 G>A was found as a decreased prostate cancer risk along with the increased variant alleles ( P <0.05 ).Specifically , participants carrying Vav 3 rs12410676 AA/AG genotypes were more likely to be at lower prostate cancer risk, compared with participants carrying GG genotypes , in groups of BMI≤25 kg/m2 , smoking, Gleason>7(4+3), and higher invasive prostate cancer .Finally, some positive findings were evidently significant&nbsp;with false positive report probability values at different prior probability levels (0.25,0.1 and 0.01).Conclusion Vav3 SNPs may contribute to the risk of prostate cancer in Eastern Chinese men , but the effect is weak and needs further validation by larger , multicenter and ethnic-based studies.