摘要目的：探讨甲状腺样滤泡性肾细胞癌的临床病理学特征。方法收集5例甲状腺样滤泡性肾细胞癌患者的临床资料，对手术标本采用HE及免疫组织化学EnVision染色进行病理学观察，并复习国内外文献报道的所有病例进行临床及病理学特征分析。结果5例中男性1例，女性4例；年龄20～55岁；3例发生于左肾，2例发生于右肾；1例于3年前曾行甲状腺乳头状癌切除术，且患者左侧腰痛、肉眼血尿2周，其余4例均无自觉临床症状及体征，无甲状腺切除史，于查体时发现肾脏占位，甲状腺检查均未见明显异常；3例行根治性肾脏切除术，2例行保留肾单位肿瘤切除术。大体检查5例肿瘤均表现为具有包膜的单发性结节状肿物，直径为2～4 cm，切面呈灰白间灰褐色；显微镜下见4例肿瘤细胞大部分排列成大小不一的甲状腺滤泡样，少部分排列成乳头状，1例滤泡样和乳头状结构的比例各占一半；滤泡样结构或乳头轴心内可见大量甲状腺滤泡胶质样物质沉积，衬覆单层柱状细胞或立方细胞，核异型性明显，部分毛玻璃样核明显，并可见核沟；免疫组织化学染色显示肿瘤细胞均表达PAX8，而甲状腺转录因子1（TTF1）、甲状腺球蛋白（Tg）均为阴性。5例中有1例在诊断的同时发生了肾门淋巴结的转移（4／4）。5例于手术后随访5～84个月，均未发生肿瘤进展。结论甲状腺样滤泡性肾细胞癌是肾原发性上皮性恶性肿瘤，确诊主要依靠其特征性的组织形态学表现，即具有与高分化甲状腺滤泡性癌／乳头状癌相似的组织学形态，病理诊断时需与甲状腺乳头状癌／滤泡癌伴肾转移相鉴别，在结合临床病史的前提下，免疫组织化学标志物TTF1和Tg在鉴别诊断时具有一定价值。

abstractsObjective To study the clinicopathologic features of thyroid-like follicular renal cell carcinoma.Methods Clinical data were collected in 5 cases of thyroid-like follicular renal cell carcinoma.HE staining and immunohistochemistry were carried out in surgically-removed specimen to analyze the clinical and pathological features with review of the literatures.Results The patients aged 20-55 years, with one male and four females;the tumor occurred in the left kidney in three cases and right kidney in two cases.One case had a history of thyroid papillary carcinoma 3 years ago, and the patient had left flank pain, macroscopic haematuria for 2 weeks.The rest four cases had no consciousness of clinical symptoms and signs, without history of thyroid gland surgery; the physical examination found a mass in the kidney and normal thyroid glands.Three patients underwent radical nephrectomy, and the other two patients underwent tumor partial nephrectomy.The tumors were 2-4 cm in size.They showed a solitary nodular mass of well circumscribed with taupe and gray on cut surface.Microscopically,most of tumor cells arranged in thyroid follicular pattern in different sizes, with papillary configuration in a small portion,in four cases;the follicular structure was intermixed with the papillary each half in one case.A large amount of thyroid colloid was deposited within follicule-like structure or papillary axis, lined by simple columnar cells or cubic cells, with obvious atypia, ground-glass nuclei, nuclear groove and rare mitosis.Immunohistochemical staining showed tumor cells were positive for PAX8,and negative for thyroid transcription factor 1 (TTF1) and thyroglobulin ( Tg).One of five patients presented with lymph node metastases (4/4) of renal hilum the same time in the diagnosis.Five cases were followed up for 5 -84 months after operation, and no tumor progression was found.Conclusions Thyroid-like follicular renal cell carcinoma is primary renal epithelial malignant tumor.The diagnosis mainly depends on its characteristics of histological appearance,namely similar to the histological morphology of well-differentiated thyroid follicular carcinoma and papillary carcinoma, and the metastasis from the thyroid papillary or follicular carcinoma must be excluded.On the premise of clinical history, immunohistochemical markers TTF1 and Tg have certain value in the differential diagnosis.