PD-1/PD-L1在三阴性乳腺癌中的表达及其意义
Expression of PD-1/PD-L1 in triple-negative breast carcinoma and its significance
摘要目的:探讨程序性死亡分子1(PD-1)和程序性死亡配体1(PD-L1)在三阴性乳腺癌中的表达及其与临床病理特征的相关性。方法采用组织芯片结合免疫组织化学方法对151例三阴性乳腺癌(病例组)及65例非三阴性乳腺癌(对照组)进行染色,观察PD-1/PD-L1在各组的表达情况,分析其与各临床病理特征的关系。结果病例组肿瘤细胞和间质肿瘤浸润淋巴细胞中PD-1/PD-L1的表达均高于对照组,差异有统计学意义( P <0.05)。其中,肿瘤细胞 PD-L1阳性率为16.6%(25/151),与高组织学级别、淋巴结转移相关(均P<0.05);间质肿瘤浸润淋巴细胞PD-L1阳性率为25.2%(38/151),与高组织学级别相关(P<0.05)。间质肿瘤浸润淋巴细胞PD-1阳性率为27.2%(41/151),与间质肿瘤浸润淋巴细胞PD-L1表达呈正相关(P<0.05)。结论 PD-L1在三阴性乳腺癌的表达与高组织学级别、淋巴结转移、间质肿瘤浸润淋巴细胞PD-1阳性相关。
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abstractsObjective To investigate the correlation between the expression of PD-1, PD-L1 and clinicopathologic parameters in triple negative breast carcinoma ( TNBC ) .Methods Samples from 151 patients with TNBC and 65 cases of other breast carcinomas ( non-TNBC) were examined for PD-L1 and PD-1 expression by immunohistochemical staining on tissue microarray .Results The expression of PD-L1 and PD-1 in the tumor cells and interstitial lymphocytes in TNBC was significantly ( P<0.05 ) higher than that in non-TNBC.In TNBC, the expression rates of PD-L1 in the cancer nests and stroma were 16.6%(25/151) and 25.2%(38/151) respectively.The former was positively correlated with tumor histological grade and lymph node metastasis (P<0.05), and the latter only with tumor histological grade (P<0.05). The expression rate of PD-1 was 27.2%(41/151), and correlated with PD-L1 expression in stromal tumor-infiltrating lymphocytes ( P <0.05 ) .Conclusion The expression of PD-L1 in TNBC is significantly correlated with high-grade histology , lymph node metastasis and PD-L1 expression in stromal tumor-infiltrating lymphocytes .
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