摘要目的探讨长链非编码RNA SNHG8在EB病毒相关胃癌中的表达及其临床意义。方法收集2012年6月至2015年4月于福建省肿瘤医院进行外科手术的93例胃癌病例（癌组织和癌旁组织）；采用EB病毒编码的小RNA（ EBER）原位杂交检测EB病毒的表达；即时荧光定量PCR验证上述组织中SNHG8的表达，并分析其与临床病理特征的关系。结果胃癌细胞核阳性的病例定义为EB病毒相关胃癌，共41例；93例胃癌患者中， SNHG8在肿瘤组织的表达比癌旁组织上调14倍（P＝0.001）；同时EB病毒相关胃癌组织SNHG8表达比EB病毒阴性胃癌组织表达上调25倍（P＝0.027）。 EB病毒相关胃癌肿瘤组织中SNHG8的表达水平与TNM分期显著相关（ P＜0.05）。结论SNHG8可能作为一个原癌基因，参与胃癌的发生发展；EB病毒感染胃黏膜可能促进SNHG8的表达，为EB病毒相关胃癌的致病机制研究提供新思路。

abstractsObjective To investigate the expression of long non-coding RNA (lncRNA) SNHG8 in EB virus related gastric cancer and their correlation prognosis.Methods The expression of SNHG8 in 93 gastric cancers and 93 cancer-free controls, matched by age and sex ,were determined by real-time PCR.EB virus expression was detected by EBER in situ hybridization.Results Forty-one gastric cancers were EB virus associated.For all gastric cancers , SNHG8 expression was 14 times higher ( P=0.001 ) than that in non-cancer controls;in the EB virus related gastric cancers , SNHG8 expression was increased 25 times ( P<0.05) over EB virus negative gastric cancers.SNHG8 expression level was also significantly associated with TNM staging ( P <0.05 ).Conclusions SNHG8 may act as a proto-oncogene , participating in gastric carcinogenesis.EB virus infection of gastric mucosa may promote SNHG 8 expression.