摘要目的 探讨孤立性纤维性肿瘤(solitary fibrous tumour,SFT)的临床病理特征及免疫组织化学标志物信号转导及转录激活因子6(signal transducers and activators of transcription 6,STAT6)的临床病理诊断意义及鉴别诊断价值.方法 对80例SFT进行回顾性研究,并复习相关文献资料,采用免疫组织化学EnVision法检测STAT6、CD34、CD99和bcl-2蛋白在SFT和其他各型软组织肿瘤中的表达情况,并分析其临床病理意义.结果 STAT6在SFT和对照组软组织肿瘤中的阳性率分别为97.5%(78/80)和3.3%(3/90),两者之间的表达差异具有统计学意义(P<0.05);在SFT中CD34、CD99和bcl-2的阳性率分别为88.8%(71/80)、76.3%(61/80)和75.0%(60/80),三者与STAT6的表达差异均具有统计学意义(P<0.05).STAT6在SFT中表达的灵敏度为97.5%(78/80),特异度为96.7%(87/90).结论 STAT6在SFT细胞核中的表达具有较高的灵敏度和特异度,远高于CD34、CD99和bcl-2这3种常用临床标志物,可作为临床诊断SFT的又一个有用标志物,具有重要的临床诊断和鉴别诊断意义.

abstractsObjective To study the clinicopathologic features, the differential diagnosis and the expression of STAT6 in solitary fibrous tumor (SFT).Methods Eighty cases of SFT were evaluated.The expression of STAT6, CD34, CD99 and bcl-2 protein was studied in these cases and in other groups of soft tissue tumors by immunohistochemical EnVision method.The results were analyzed and relevant literature were reviewed.Results The expression rate of STAT6 in SFT was 97.5% (78/80) and that in other soft tissue tumors was 3.3% (3/90).The difference was significant (P<0.05).The expression rates of CD34, CD99 and bcl-2 were 88.8% (71/80), 76.3% (61/80) and 75.0% (60/80) in SFT, respectively, which were significantly different from STAT6 expression rate (P<0.05).Conclusions The expression of STAT6 in SFT has high sensitivity (97.5%) and specificity (96.7%).The expression of STAT6 in SFT is higher than that of CD34, CD99 and bcl-2.STAT6 may be a useful marker for clinical diagnosis of SFT.