摘要目的 分析表达突触素的胃血管球瘤的临床病理特征及其与胃神经内分泌肿瘤的鉴别.方法 收集温州医科大学附属台州医院病理科2010年1月至2016年6月连续诊断的6例胃血管球瘤,8例其他部位的血管球瘤,7例胃神经内分泌肿瘤,分析其临床病理特征及免疫组织化学标记.结果 胃血管球瘤大多发生在胃窦部的固有肌层,弥漫强表达突触素(5/6),而在其他部位的血管球瘤无突触素表达.胃神经内分泌肿瘤大多发生在胃底、胃体部的黏膜层和黏膜下层,除弥漫强表达突触素(7/7)外,还高表达嗜铬粒素A(6/7)、CD56(5/7),不表达平滑肌肌动蛋白(0/7).结论胃血管球瘤与神经内分泌肿瘤的形态学有些相似性,且均可以强表达突触素,但其好发部位及免疫标记有显著不同可资鉴别.

abstractsObjective To investigate the clincopathologic and immunohistochemical features of gastric glomus tumors and their differences from gastric neuroendocrine neoplasms. Methods Six cases of gastric glomus tumors, 8 cases of glomus tumors in other sites and 7 cases of gastric neuroendocrine neoplasms were collected from the Department of Pathology,Taizhou Hospital. The clinicopathological and immunohistochemical characteristics of these tumors were analyzed retrospectively. Results The gastric glomus tumors were located in the muscularis propria of the antrum and most cases strongly expressed synaptophysin(5/6). However, no synaptophysin expression was seen in glomus tumors of other organs.Most gastric neuroendocrine neoplasms were located in the mucosa or submucosa of the fundus and corpus. In addition to the strong expression of synaptophysin(7/7),CgA(6/7)and CD56(5/7)were strongly positive, although SMA was negative. Conclusions Gastric glomus tumors and neuroendocrine neoplasms have similar morphological characteristics and both show strongly expression of synaptophysin. However,the location and immunohistochemical characteristics of gastric glomus tumors differ from those of the neuroendocrine neoplasms.