摘要目的 探讨阴道壁管状鳞状上皮息肉的临床病理学特征,以进一步认识此类病变.方法 收集2007年至2018年浙江大学医学院附属妇产科医院4例阴道壁管状鳞状上皮息肉的患者临床病理学资料,免疫组织化学染色采用EnVision二步法,观察病变的组织学特征并总结其临床病理学特点.结果 4例患者发病年龄为62~71岁(平均66岁),均为阴道壁赘生物摘除标本.镜下观察, 4例病变主要由良性的鳞状上皮和管状结构组成,位于纤维血管间质内.免疫组织化学证实4例管状结构均不同程度表达前列腺标志物(前列腺特异性抗原和/或前列腺酸性磷酸酶).4例患者中3例有随访资料,随访时间4~6个月(平均5.3个月),均无复发.结论 阴道壁管状鳞状上皮息肉具有独特的组织学特征,对其研究较少,易造成漏诊,其来源还有待进一步研究.

abstractsObjective To investigate clinicopathological characteristics of vaginal tubulo?squamous polyp (TSP). Methods Clinical and pathological data of 4 cases of vaginal TSP diagnosed at Women′s Hospital, School of Medicine, Zhejiang University from 2007 to 2018 were analyzed by hematoxylin?eosin and EnVision two?step immunohistochemical staining technique. Results The age of the 4 patients ranged from 62 to 71 years, with a mean of 66 years. Histologically, the polyps consisted of an admixture of squamous epithelium and tubules within a fibrous stroma. Immunohistochemically, the cells lining the tubules showed positive staining of prostatic acid phosphatase (PSAP) and/or prostate?specific antigen (PSA) in all 4 cases. Available follow?up in 3 patients for 4 to 6 months (mean of 5.3 months) showed no tumor recurrence. Conclusion TSP is an under?recognized benign vaginal polypoid disease that may develop from paraurethral Skene glands.