摘要目的:在证实巨细胞病毒（CMV）感染的病例中比较左半及右半结肠CMV包涵体检出量差异，以指导临床内镜活检部位。方法:收集中国医学科学院北京协和医学院北京协和医院2015年7月至2018年7月经组织学证实的肠道CMV感染患者731例，以脾曲为左半、右半结肠的分界，选取左半及右半结肠同时均有组织学标本并证实存在CMV感染的患者10例。其中男性7例，女性3例，年龄29~66岁，中位年龄55岁，10例患者诊断均为溃疡性结肠炎。组织学活检及手术标本共25份，HE切片观察组织学形态，用免疫组织化学EnVision法检测CMV感染细胞。通过组织学及免疫组织化学染色结果将左半及右半结肠感染细胞的个数进行对比。结果:活检及手术标本中可见左半结肠感染CMV细胞个数为115（1~41）个，右半结肠感染CMV细胞个数为76（0~51）个，8/10患者左半结肠CMV包涵体检出个数高于右半结肠。结论:活检及手术标本中提示CMV感染检出多位于左半结肠，提示左半结肠为内镜疑似CMV感染时的重要活检部位。

abstractsObjective:To compare the differences in the detection rates of cytomegalovirus (CMV) infection between the left and right colons for guiding endoscopic biopsy-sites.Methods:The cases of colonic CMV infection confirmed by histology at the Peking Union Medical College Hospital from July 2015 to July 2018 were collected and analyzed. Splenic curvature was used as the dividing point between the left and right colons. The CMV inclusions were identified histologically, and the CMV infected cells were detected using immunohistochemistry (EnVision method). The numbers of infected cells in the left and right colons were compared by histological and immunohistochemical results. A total of 731 patients were identified. Ten of the 731 patients had histological specimens of both left and right colons and were confirmed with CMV EnVision immunohistochemical study. There were 25 biopsy or resection specimens. Seven patients were male and 3 were female, and their ages ranged from 29 to 66 years, with a median age of 55 years. All of the 10 patients were also diagnosed with ulcerative colitis.Results:The number of the cells infected with CMV in the left colon was 115 (1-41), while that in the right colon was 76 (0-51). In 8/10 cases, the number of CMV infected cells in the left colon was more than that in the right colon.Conclusions:The study on the biopsies and resection specimens suggests that CMV infection is mostly present in the left colon. The left colon thus might be an important endoscopic biopsy-site for the cases with suspicion of CMV infection.