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Differential mRNA expression of Sporothrix schenckii catalase gene in two growth phases and effect factors

摘要:

篇首: Sporothrix schenckii (S. schenckii), a dimorphic fungus, is the etiological agent of sporotrichosis. After entrance of microconidia or mycelial fragments into a mammalian host, the fungus differentiates into the parasitic yeast form. Meanwhile, several defensive signals would be triggered when the innate immune system was stimulated by 5. schenckii invasion and microbe-specific phagocytosis. The success of 5. schenckii infection partly depends on its ability to avoid oxidative damage from reactive oxygen species (ROS) released by polymorphonuclear leukocytes and activated macrophages. However, the antioxidant defense mechanisms of S. schenckii remains unknown. Catalases, one of the central enzymes involved in scavenging ROS via converting hydrogen peroxide (H2O2) to water and molecular oxygen, play an essential role in protecting intracellular pathogenic fungi against ROS1,2 and regulating growth and development in some fungi.3'4 No catalase in 5. schenckii has been identified and characterized previously. Recently we have cloned a catalase homologous gene from the yeast form of 5. schenckii and designated it Sscat. In this report, we used quantitative real-time polymerase chain reaction (PCR) to measure and compare mRNA expression of Sscat in the mycelium-to-yeast transition and H2O2-challenge induced microenvironments in vitro. The results presented may help in understanding the role of 5. schenckii catalase in the fungus-host interaction with respect to ROS.

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作者单位: Department of Dermatology, Second Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China [1] Department of Dermatology, First Hospital of Peking University;Research Center for Medical Mycology, Peking University, Beijing 100034, China [2] ycology, Peking University, Beijing 100034, China [3] Department of Geriatriacs, First Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China [4]
期刊: 《中华医学杂志(英文版)》2008年121卷20期 2100-2102页 SCIMEDLINEISTICCSCDBP
分类号: R5
栏目名称: Brief report
发布时间: 2009-01-07
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