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Tumor-associated macrophages: a novel potential target for cancer treatment

摘要:

Special emphasis about cancer metastasis was concentrated on tumor cells themselves,and we usually considered the ability of migration and invasion was the final decider.Recently,bewaring of tumor microenvironment is a fundamental determinant in metastasis has become the most outstanding breakthrough.Considerable “microbes” in the microenvironment are closely linked with tumor metastatic behaviors,and the major proportion of them is tumor-associated macrophages (TAMs).Actually,TAMs conserve immediate “cross-talk” with cancer cells throughout tumor development.It is generally accepted that TAMs have mostly pro-tumoral functions and play an important role in several stages of tumor progression.This progression involves a series of events that leads from the primary site to the metastatic site,including tumor cell growth,angiogenesis,migration,invasion,intravasation and finally extravasation at distant site where the process begins again (metastasis).Thereby,TAMs has attracted substantial attentions in recent years and could become a promising therapeutic strategy.In this review,we focus on the multi-functions of TAMs in cancer and certain drugs targeting TAMs for cancer treatment those are under experimental research procedures or have even been entered human clinical tests.

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作者单位: Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine,Nanjing, Jiangsu 210029, China [1] Fujian Provincial Hospital, Clinical College of Fujian Medical University, Fuzhou, Fujian 350001, China ;Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine,Nanjing, Jiangsu 210029, China [2] Jiangsu Key Laboratory for Evaluation of Pharmcodynamics and Safety Evaluation of Chinese Materia Medica , Nanjing University of Chinese Medicine,Nanjing, Jiangsu 210029, China;Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine,Nanjing, Jiangsu 210029, China [3]
期刊: 《中华医学杂志(英文版)》2012年125卷18期 3305-3311页 SCIMEDLINEISTICCSCDBP
栏目名称: MEDICAL PROGRESS
DOI: 10.3760/cma.j.issn.0366-6999.2012.18.020
发布时间: 2013-01-25
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