• 医学文献
  • 知识库
  • 评价分析
  • 全部
  • 中外期刊
  • 学位
  • 会议
  • 专利
  • 成果
  • 标准
  • 法规
  • 临床诊疗知识库
  • 中医药知识库
  • 机构
  • 作者
热搜词:
换一批
论文 期刊
取消
高级检索

检索历史 清除

医学文献 >>
  • 全部
  • 中外期刊
  • 学位
  • 会议
  • 专利
  • 成果
  • 标准
  • 法规
知识库 >>
  • 临床诊疗知识库
  • 中医药知识库
评价分析 >>
  • 机构
  • 作者
热搜词:
换一批

Telithromycin versus clarithromycin for the treatment of community-acquired respiratory tract infections: a meta-analysis of randomized controlled trials

摘要:

Background The emergence of bacterial resistance to commonly used antibiotics,such as macrolides,is complicating the management of respiratory tract infections (RTIs).Telithromycin,a ketolide antimicrobial structurally related to macrolides,is approved for the treatment of community-acquired RTIs,and shows lower pathogen resistance rates.The purpose of this study was to compare the efficacy and safety of telithromycin with clarithromycin,a macrolide routinely used as therapy for RTIs.Methods We performed a meta-analysis of relevant randomized-controlled trials (RCTs) identified in PubMed,the Cochrane Library,Embase,CNKI and VIP databases.The primary efficacy outcome was clinical treatment success assessed at the test-of-cure time in the per-protocol population,and the primary safety outcome was drug related adverse effects.Results Seven RCTs,involving 2845 patients with RTIs,were included in the meta-analysis.Oral telithromycin and clarithromycin showed a similar clinical treatment success in modified intention to treat and per-protocol population (cure and improvement) (odds ratios (ORs):0.84,95% confidence intervals (CI):0.64-1.11 and OR:1.14,95% CI:0.71-1.85,respectively).Similar findings were obtained for secondary efficacy outcomes:clinical treatment success at a late posttherapy visit (OR:0.92,95% CI:0.57-1.48) and microbiological treatment success at the test-of-cure time (OR:1.14; 95%CI:0.71-1.85).The safety outcome analysis indicated telithromycin had a similar risk of drug-related adverse effect and serious adverse effect with clarithromycin.Conclusions Our findings indicate that oral telithromycin and clarithromycin have similar treatment efficacy and adverse effect.The advantages of lower antimicrobial resistance rates,once-daily short-duration dosing and reported lower healthcare costs make oral telithromycin a useful option for the empiric management of mild-to-moderate RTIs.

更多
作者单位: Department of Pharmacy,Military General Hospital of Beijing PLA,Beijing 100700,China [1]
期刊: 《中华医学杂志(英文版)》2013年126卷11期 2179-2185页 SCIMEDLINEISTICCSCDBP
栏目名称: METAANALYSIS
DOI: 10.3760/cma.j.issn.0366-6999.20122745
发布时间: 2013-07-26
翻译满意度评价:
提交
  • 浏览:113
  • 下载:8

加载中!

相似文献

  • 中文期刊
  • 外文期刊
  • 学位论文
  • 会议论文

加载中!

加载中!

加载中!

加载中!

特别提示:本网站仅提供医学学术资源服务,不销售任何药品和器械,有关药品和器械的销售信息,请查阅其他网站。

  • 客服热线:4000-115-888 转3 (周一至周五:8:00至17:00)

  • |
  • 客服邮箱:yiyao@wanfangdata.com.cn

  • 违法和不良信息举报电话:4000-115-888,举报邮箱:problem@wanfangdata.com.cn,举报专区

官方微信
万方医学小程序
new翻译 充值 订阅 收藏 移动端

官方微信

万方医学小程序

使用
帮助
Alternate Text
调查问卷