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Impact of microbubble enhanced, pulsed, focused ultrasound on tumor circulation of subcutaneous VX2 cancer

摘要:

Background Intravascular microbubble-enhanced acoustic cavitation is capable of disrupting the vascular walls of capillaries and small vessels.This study was designed to investigate the impact of microbubble-enhanced,pulsed and focused ultrasound (MEUS) on the blood perfusion of subcutaneous VX2 tumors in rabbits.Methods Subcutaneous VX2 cancers in twenty New Zealand rabbits were treated by combining high-pressure amplitude,pulsed and focused therapeutic ultrasound (TUS) and intravenous microbubble injections.The TUS transducer was operated with a peak negative pressure of 4.6 MPa and a duty cycle of 0.41%.Controls were subcutaneous VX2 cancers treated with TUS or microbubbles only.Contrast-enhanced ultrasound (CEUS) and intravenous Evans Blue (EB) perfusion were performed to assess the tumor circulation.The tumor microvascular disruption was assessed by histological examination.Results CEUS showed that the tumor circulation almost vanished after MEUS treatment.The average peak grayscale value (GSV) of tumor CEUS dropped significantly from 84.1±22.4 to 15.8±10.8 in the MEUS-treated tumors but no significant GSV changes were found in tumors in the two control groups.The mean tumor EB content of the MEUS-treated tumors was significantly lower than that of the controls.Histological examination found scattered tumor microvascular disruption with intercellular edema after MEUS treatment.Conclusion The tumor circulation of VX2 cancers can be arrested or significantly reduced by MEUS due to microvascular disruption.

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作者单位: Department of Ultrasound, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China ;Department of Ultrasound, General Hospital of Jinan Military Area, Jinan, Shandong 250000, China [1] Department of Ultrasound, First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan 650032, China [2] Department of Ultrasound, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China [3]
期刊: 《中华医学杂志(英文版)》2014年127卷14期 2605-2611页 SCIMEDLINEISTICCSCDBP
栏目名称: ORIGINAL ARTICLES
DOI: 10.3760/cma.j.issn.0366-6999.20133110
发布时间: 2014-08-22
基金项目:
This study was supported by grants from the National Natural Science Foundation of China the National High-tech R&D Program the Chongqing Science and Technology Project
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