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Genetics of obstructive sleep apnea/hypopnea syndrome

摘要:

Objective To have a better understanding of genetic contributions to the development of obstructive sleep apnea hypopnea syndrome (OSAHS) by reviewing studies on its genetic basis.Data sources A comprehensive search of the PubMed literature without restriction on the publication date was carried out using terms "obstructive sleep apnea" and "candidate genes" or "genetics".Study selection Articles were selected if they were an original research paper or meta analysis of the genetic factors of OSAHS.Results Four intermediate phenotypes were described and several candidate genes that may determine the expression and severity of OSAHS were reviewed.Conclusion Multiple gene-gene interactions occurring in genes that affect obesity,craniofacial structure,ventilator control and asleep-awake pattern may influence the expression of OSAHS in a suitable environment.

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作者单位: Department of Internal Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China [1] Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China [2]
期刊: 《中华医学杂志(英文版)》2014年127卷17期 3135-3141页 SCIMEDLINEISTICCSCDBP
栏目名称: REVIEW ARTICLES
DOI: 10.3760/cma.j.issn.0366-6999.20141068
发布时间: 2014-10-09
基金项目:
The study was supported by a grant from the National Key Technology R&D Program
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