To the Editor: Diabetic kidney disease (DKD) is the most common cause of end?stage renal disease (ESRD); however, the onset of DKD is difficult to detect.[1] When persistent microalbuminuria becomes detectable, DKD has already progressed to the third disease stage, and finding biomarkers that are more sensitive than microalbuminuria is therefore necessary to indicate kidney damage at an earlier stage of DKD.[2] Both glomerular and tubulointerstitial damages have been repeatedly demonstrated to be important factors in the pathophysiology of DKD.[3] Therefore, we investigated the expression levels of six markers closely related to the glomerulus and renal tubule.
作者单位:Department of Nephrology, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing 100853, China[1]Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Research Institute of Nephrology in Zhengzhou University, Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, Henan 450052, China[2]
This study was supported by the grants from the National Key R&D Program of Chinathe National Natural Science Foundation of Chinathe Joint Funds of National Natural Science Foundation of China and Henan Provincethe Special Research Project on Health Care of the Chinese People's Liberation Army