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Olfactomedin-like 3: possible functions in embryonic development and tumorigenesis

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Objective:Modern medical research has proven that human diseases are directly or indirectly related to genes.At the same time,genetic research has also brought updates to diagnostic techniques.Olfactomedin-like 3 (OLFML3) gene is a novel and clinically valuable gene.In order to better understand the role of OLFML3 in human diseases,we discuss and analyze the characteristics,function,and regulation mechanism of the OLFML3 gene in this review.Data sources:A comprehensive search in PubMed and ScienceDirect database for English up to March 2019,with the keywords of "Olfactomedin-like 3," "Olfactomedin," "extracellular matrix," "Transforming Growth Factor β1," "anoikis-resistance," and "microRNA-155." Study selection:Careful review of all relevant literature,the references of the retrieved articles were also screened to search for potentially relevant papers.Results:OLFML3 is a secreted glycoprotein with 406 amino acid residues,belonging to the Olfactomedin (OLF) family.Due to the particularity of its structure and differential expression,OLFML3 has unique biological functions that could be distinct from other members in the OLF family.The currently known functions include embryonic development function and tumorigenesis.The regulation mechanism is still under investigation.It is directly related to many human diseases.Conclusions:OLFML3 is a mukifunctional glycoprotein that is closely involved in embryonic development,tumor invasion,and metastasis.Unfortunately,current research on this important molecule is still very limited.Further investigations on the possible mechanism of OLFML3 biological functions and modulation will help us develop better diagnostics and treatments.

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作者单位: Department of Obstetrics and Gynaecology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China [1] Institute of Translational and Stratified Medicine, Plymouth University Faculty of Medicine and Dentistry, Plymouth PL6 8BU, the United Kingdom [2]
期刊: 《中华医学杂志(英文版)》2019年132卷14期 1733-1738页 SCIMEDLINEISTICCSCDBP
栏目名称: Review Articles
DOI: 10.1097/CM9.0000000000000309
发布时间: 2019-08-28
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