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目的了解兔胸部火器伤血浆中肾上腺素（epinephrine， E）和去甲肾上腺素(norepinephrine， NE )变化规律及在伤后应激反应中的作用。方法将24只家兔随机分为:单纯胸腔贯穿伤组(A组)、假致伤组(B组)和正常对照组(C组)。射击前A、B组右颈总动脉及右颈外静脉插管、C组耳中动、静脉头皮针穿刺接八道生理记录仪测压。伤前5 min、伤后5，30 min、1，3，6，12，24 h取动脉血 2 ml离心出血浆，采用高效液相色谱仪（high-performance liquid chromatography， HPLC）与电化学分析（electrochemical detection， ED）检测 E及NE含量。结果 (1)A组E及NE于伤后30 min达伤前4.13和3.45倍，分别于伤后1，3 h降至最低点，为伤前 2.57和 0.47倍，于6 h达第二高峰，为伤前 4.14和 3.68倍，24 h后降至伤前水平；B、C组E及NE比较，差异无显著性意义（P>0.05）。 (2)A组动、静脉压致伤瞬间（ 2 ms内）升高，平均达伤前的1.8和6.8倍，迅即下降至伤前水平，随后缓慢下降，分别于伤后30， 5 min降至最低点（伤前的0.63和 0.25倍），之后缓慢回升，6，12 h接近伤前水平；B、C组动、静脉压比较，差异无统计学意义（P>0.05）。结论兔胸部火器伤后血浆中 E和NE均显著升高；二者浓度变化主要源自创伤后失血及组织损伤，且与伤情轻重关系密切，可作为胸部火器伤后早期伤情程度的判断标准。

Objective　To investigate the changes of plasma epinephrine (E) and norepinephrine (NE) in rabbits with firearm thoracic wounds. 　Methods　 A total of 24 rabbits were divided into 3 groups randomly, the simple thoracic penetrating injury group (Group A, n = 8), the pseudo-injury group (Group B, n = 8)and the normal control group ( Group C, n = 8). The pressures of carotid artery and jugular vein were recorded by eight-road physiological recorder at 5 minutes before injury. And the concentrations of plasma E and NE were detected through high-performance liquid chromatography (HPLC) and electrochemical detection (ED) at 5 minutes, 30 minutes, 1 hour, 3 hours, 6 hours, 12 hours and 24 hours after injury in all the rabbits. 　Results　The concentrations of plasma E and NE in Group A were significantly higher than those of Group C (P<0.01) and changed regularly. There was no significant difference between Group B and Group C. The pressures of carotid artery and jugular vein of Group A increased by 1.8 and 6.8 times, respectively, during 2 millisecond after injury, then decreased to normal immediately. They decreased to the minimum (0.63 and 0.25 time, respectively) in 30 minutes and 5 minutes respectively and averagely, and raised to normal slowly after 6 hours and 12 hours respectively and averagely. There was no significant difference between Group B and Group C.　Conclusions 　 The concentrations of plasma E and NE increase significantly in the rabbits with thoracic firearm wounds. Their changes have close relationship with the severity of wound and can be used as a judging criterion during the early period of wound.