绝经后女性特发性良性阵发性位置性眩晕患者骨代谢的研究
Study on bone metabolism in postmenopausal women with idiopathic benign paroxysmal positional vertigo
目的 分析绝经后女性特发性良性阵发性位置性眩晕(benign paroxysmal positional vertigo,BPPV)患者的骨密度和血骨钙素情况.方法 选择就诊于宁波市第二医院神经内科的64例绝经后女性特发性BPPV患者作为研究对象,选择同期98例绝经后健康女性作为对照组,比较2组的骨密度和血骨钙素结果.计数资料采用χ2检验,正态分布的计量资料采用t检验.结果 BPPV组中患者骨量减少、骨质疏松的发生率为67.2%(43/64),高于对照组的51.0%(50/98),差异有统计学意义(χ2=4.139,P=0.042).在BPPV组中,骨钙素和骨密度T值之间呈负相关(r=-0.469,P<0.001).在BPPV组骨量正常、骨量减少和骨质疏松3个亚组中,骨钙素分别为(13.61 ±4.32)μg/L、(17.49 ±7.61)μg/L和(20.83 ±6.72)μg/L,差异有统计学意义(F=5.39,P=0.007).结论 绝经后女性特发性BPPV患者的骨密度水平较低,BPPV组中骨密度越低的患者,骨钙素越高.
更多Objective To analyze the bone mineral density and serum osteocalcin levels in postmenopausal women with idiopathic benign paroxysmal positional vertigo.Methods A total of 64 postmenopausal women with idiopathic BPPV were selected as the study group, and 98 postmenopausal healthy women were selected as the control group.Bone mineral density and serum osteocalcin levels were analyzed and compared between the groups.χ2test was used for numeration data and t test was used for measurement data.Results The prevalence of osteoporosis or osteopenia in BPPV group 67.2%(43/64) was significantly higher than that in the control group 51.0%(50/98)(χ2=4.139, P=0.042).Among BPPV subjects,there was a negative correlation between osteocalcin and bone density T(r=-0.469,P<0.001).Osteocalcin was found in normal bone mass subgroup(13.61 ±4.32)μg/L,decreased bone mass subgroup(17.49 ±7.61)μg/L, and osteoporosis subgroup(20.83 ±6.72)μg/L, respectively, and the difference was statistically significant(F=5.39,P=0.007).Conclusions Bone mineral density in BPPV group is lower than that in control group.The lower the bone mineral density of the patients,the higher the osteocalcin in BPPV group.
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